The role of orphan nuclear receptors in the regulation of cholesterol homeostasis

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530 Citations (Scopus)

Abstract

Cholesterol balance is maintained by a series of regulatory pathways that control the acquisition of cholesterol from endogenous and exogenous sources and the elimination of cholesterol, facilitated by its conversion to bile acids. Over the past decade, investigators have discovered that a family of membrane-bound transcription factors, sterol regulatory element-binding proteins (SREBPs), mediate the end-product repression of key enzymes of cholesterol biosynthesis. Recently orphan members of another family of transcription factors, the nuclear hormone receptors, have been found to regulate key pathways in bile acid metabolism, thereby controlling cholesterol elimination. The study of these orphan nuclear receptors suggests their potential as targets for new drug therapies.

Original languageEnglish (US)
Pages (from-to)459-481
Number of pages23
JournalAnnual Review of Cell and Developmental Biology
Volume16
DOIs
StatePublished - 2000

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Orphan Nuclear Receptors
Homeostasis
Cholesterol
Bile Acids and Salts
Enzyme Repression
Transcription Factors
Sterol Regulatory Element Binding Proteins
Cytoplasmic and Nuclear Receptors
Research Personnel
Drug Therapy
Membranes

Keywords

  • Bile acids
  • FXR
  • LXR
  • Oxysterols
  • RXR

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

Cite this

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AB - Cholesterol balance is maintained by a series of regulatory pathways that control the acquisition of cholesterol from endogenous and exogenous sources and the elimination of cholesterol, facilitated by its conversion to bile acids. Over the past decade, investigators have discovered that a family of membrane-bound transcription factors, sterol regulatory element-binding proteins (SREBPs), mediate the end-product repression of key enzymes of cholesterol biosynthesis. Recently orphan members of another family of transcription factors, the nuclear hormone receptors, have been found to regulate key pathways in bile acid metabolism, thereby controlling cholesterol elimination. The study of these orphan nuclear receptors suggests their potential as targets for new drug therapies.

KW - Bile acids

KW - FXR

KW - LXR

KW - Oxysterols

KW - RXR

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