The role of phenotyping in chronic prostatitis/chronic pelvic pain syndrome

Brandon A. Mahal, Jeffrey M. Cohen, Stephen A. Allsop, John B. Moore, Salman F. Bhai, Gino Inverso, Jordan D. Dimitrakoff

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a chronic pain syndrome identified by the presence of noninfectious pelvic or perineal pain lasting longer than 3 months. Current diagnoses and treatments for the syndrome solely depend on and target symptoms, respectively. Thus far, the mechanistic disturbances responsible for the pathogenesis of CP/CPPS have remained largely elusive and treatments, and therefore, continue to be ineffective. To move toward successful management and treatment of CP/CPPS, it is necessary to elicit the underlying biological mechanisms responsible for the syndrome. Therefore, a phenotyping system that is able to bridge the gap between current symptom-based diagnosis and future mechanistic approaches to diagnosis and treatment is needed. In this article, we examine current CP/CPPS phenotyping systems, analyze their utility, and make suggestions for changes in clinical approaches to the syndrome that would both promulgate a mechanistic understanding and advance treatment approaches.

Original languageEnglish (US)
Pages (from-to)297-303
Number of pages7
JournalCurrent urology reports
Volume12
Issue number4
DOIs
StatePublished - Aug 2011
Externally publishedYes

Keywords

  • Chronic prostatitis/chronic pelvic pain syndrome
  • CP/CPPS
  • DABBEC
  • Phenotype
  • Phenotyping
  • UPOINT

ASJC Scopus subject areas

  • Urology

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