The Role of PIAS SUMO E3-Ligases in Cancer

Andrea Rabellino, Cristina Andreani, Pier Paolo Scaglioni

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

SUMOylation modifies the interactome, localization, activity, and lifespan of its target proteins. This process regulates several cellular machineries, including transcription, DNA damage repair, cell-cycle progression, and apoptosis. Accordingly, SUMOylation is critical in maintaining cellular homeostasis, and its deregulation leads to the corruption of a plethora of cellular processes that contribute to disease states. Among the proteins involved in SUMOylation, the protein inhibitor of activated STAT (PIAS) E3-ligases were initially described as transcriptional coregulators. Recent findings also indicate that they have a role in regulating protein stability and signaling transduction pathways. PIAS proteins interact with up to 60 cellular partners affecting several cellular processes, most notably immune regulation and DNA repair, but also cellular proliferation and survival. Here, we summarize the current knowledge about their role in tumorigenesis and cancer-related processes.

Original languageEnglish (US)
Pages (from-to)1542-1547
Number of pages6
JournalCancer Research
Volume77
Issue number7
DOIs
StatePublished - 2017

Fingerprint

Protein Inhibitors of Activated STAT
Sumoylation
Ubiquitin-Protein Ligases
DNA Repair
Neoplasms
Proteins
Protein Stability
DNA Damage
Cell Cycle
Carcinogenesis
Homeostasis
Cell Proliferation
Apoptosis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

The Role of PIAS SUMO E3-Ligases in Cancer. / Rabellino, Andrea; Andreani, Cristina; Scaglioni, Pier Paolo.

In: Cancer Research, Vol. 77, No. 7, 2017, p. 1542-1547.

Research output: Contribution to journalReview article

Rabellino, Andrea ; Andreani, Cristina ; Scaglioni, Pier Paolo. / The Role of PIAS SUMO E3-Ligases in Cancer. In: Cancer Research. 2017 ; Vol. 77, No. 7. pp. 1542-1547.
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