TY - JOUR
T1 - The Role of PIAS SUMO E3-Ligases in Cancer
AU - Rabellino, Andrea
AU - Andreani, Cristina
AU - Scaglioni, Pier Paolo
N1 - Publisher Copyright:
© 2017 American Association for Cancer Research.
PY - 2017
Y1 - 2017
N2 - SUMOylation modifies the interactome, localization, activity, and lifespan of its target proteins. This process regulates several cellular machineries, including transcription, DNA damage repair, cell-cycle progression, and apoptosis. Accordingly, SUMOylation is critical in maintaining cellular homeostasis, and its deregulation leads to the corruption of a plethora of cellular processes that contribute to disease states. Among the proteins involved in SUMOylation, the protein inhibitor of activated STAT (PIAS) E3-ligases were initially described as transcriptional coregulators. Recent findings also indicate that they have a role in regulating protein stability and signaling transduction pathways. PIAS proteins interact with up to 60 cellular partners affecting several cellular processes, most notably immune regulation and DNA repair, but also cellular proliferation and survival. Here, we summarize the current knowledge about their role in tumorigenesis and cancer-related processes.
AB - SUMOylation modifies the interactome, localization, activity, and lifespan of its target proteins. This process regulates several cellular machineries, including transcription, DNA damage repair, cell-cycle progression, and apoptosis. Accordingly, SUMOylation is critical in maintaining cellular homeostasis, and its deregulation leads to the corruption of a plethora of cellular processes that contribute to disease states. Among the proteins involved in SUMOylation, the protein inhibitor of activated STAT (PIAS) E3-ligases were initially described as transcriptional coregulators. Recent findings also indicate that they have a role in regulating protein stability and signaling transduction pathways. PIAS proteins interact with up to 60 cellular partners affecting several cellular processes, most notably immune regulation and DNA repair, but also cellular proliferation and survival. Here, we summarize the current knowledge about their role in tumorigenesis and cancer-related processes.
UR - http://www.scopus.com/inward/record.url?scp=85017337605&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85017337605&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-16-2958
DO - 10.1158/0008-5472.CAN-16-2958
M3 - Review article
C2 - 28330929
AN - SCOPUS:85017337605
SN - 0008-5472
VL - 77
SP - 1542
EP - 1547
JO - Cancer research
JF - Cancer research
IS - 7
ER -