The role of PPARαin autosomal dominant polycystic kidney disease

Research output: Contribution to journalReview article

Abstract

Purpose of reviewMetabolic reprogramming is a prominent feature of cyst epithelial cells in autosomal dominant polycystic kidney disease (ADPKD). Peroxisome proliferator activated receptor alpha (PPARα) is a transcription factor that regulates many aspects of cellular metabolism. The purpose of this review is to understand the role of PPARα in ADPKD.Recent findingsPPARα expression is reduced in ADPKD kidneys of mice and humans. This downregulation is in part secondary to microRNA mediated translational repression and leads to impairment of fatty acid metabolism. Genetic studies demonstrate that deletion of Pparα aggravates cyst growth in a slowly progressive mouse model of ADPKD. Recent studies also show that administration of Pparα agonists ameliorates cyst burden in mice.SummaryAbnormal reduction of PPARα affects cellular metabolism in ADPKD. Pparα is a modulator of cyst progression in mouse models of ADPKD. These studies establish PPARα as an exciting new drug target for the treatment of individuals with ADPKD.

Original languageEnglish (US)
Pages (from-to)432-438
Number of pages7
JournalCurrent opinion in nephrology and hypertension
Volume29
Issue number4
DOIs
StatePublished - Jul 1 2020

Keywords

  • ADPKD
  • PPARα
  • metabolism

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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