TY - JOUR
T1 - The role of prostatitis in prostate cancer
T2 - Meta-analysis
AU - Jiang, Junyi
AU - Li, Jinyi
AU - Zhang, Yunxia
AU - Zhu, Hong
AU - Liu, Junjiang
AU - Pumill, Chris
PY - 2013/12/31
Y1 - 2013/12/31
N2 - Objective: Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model. Evidence Acquisition: Case control studies of prostate cancer with information on prostatitis history. All studies published between 1990-2012, were collected to calculate a pooled odds ratio. Selection criteria: the selection criteria are as follows: human case control studies; published from May 1990 to July 2012; containing number of prostatitis, and prostate cancer cases. Evidence Synthesis: In total, 20 case control studies were included. A significant association between prostatitis and prostate cancer was found, under both fixed effect model (pooled OR=1.50, 95% CI: 1.39-1.62), and random effects model (OR=1.64, 95% CI: 1.36-1.98). Personal interview based case control studies showed a high level of association (fixed effect model: pooled OR=1.59, 95% CI: 1.47-1.73, random effects model: pooled OR= 1.87, 95% CI: 1.52-2.29), compared with clinical based studies (fixed effect model: pooled OR=1.05, 95% CI: 0.86-1.28, random effects model: pooled OR= 0.98, 95% CI: 0.67-1.45). Additionally, pooled ORs, were calculated for each decade. In a fixed effect model: 1990's: OR=1.58, 95% CI: 1.35-1.84; 2000's: OR=1.59, 95% CI: 1.40-1.79; 2010's: OR=1.37, 95% CI: 1.22-1.56. In a random effects model: 1990's: OR=1.98, 95% CI: 1.08-3.62; 2000's: OR=1.64, 95% CI: 1.23-2.19; 2010's: OR=1.34, 95% CI: 1.03-1.73. Finally a meta-analysis stratified by each country was conducted. In fixed effect models, U.S: pooled OR =1.45, 95% CI: 1.34-1.57; China: pooled OR =4.67, 95% CI: 3.08-7.07; Cuba: pooled OR =1.43, 95% CI: 1.00-2.04; Italy: pooled OR =0.61, 95% CI: 0.13-2.90. In random effects model, U.S: pooled OR=1.50, 95% CI: 1.25-1.80; China: pooled OR =4.67, 95% CI: 3.08-7.07; Cuba: pooled OR =1.43, 95% CI: 1.00-2.04; Italy: pooled OR =0.61, 95% CI: 0.13-2.90. CONCLUSIONS: the present meta-analysis provides the statistical evidence that the association between prostatitis and prostate cancer is significant.
AB - Objective: Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model. Evidence Acquisition: Case control studies of prostate cancer with information on prostatitis history. All studies published between 1990-2012, were collected to calculate a pooled odds ratio. Selection criteria: the selection criteria are as follows: human case control studies; published from May 1990 to July 2012; containing number of prostatitis, and prostate cancer cases. Evidence Synthesis: In total, 20 case control studies were included. A significant association between prostatitis and prostate cancer was found, under both fixed effect model (pooled OR=1.50, 95% CI: 1.39-1.62), and random effects model (OR=1.64, 95% CI: 1.36-1.98). Personal interview based case control studies showed a high level of association (fixed effect model: pooled OR=1.59, 95% CI: 1.47-1.73, random effects model: pooled OR= 1.87, 95% CI: 1.52-2.29), compared with clinical based studies (fixed effect model: pooled OR=1.05, 95% CI: 0.86-1.28, random effects model: pooled OR= 0.98, 95% CI: 0.67-1.45). Additionally, pooled ORs, were calculated for each decade. In a fixed effect model: 1990's: OR=1.58, 95% CI: 1.35-1.84; 2000's: OR=1.59, 95% CI: 1.40-1.79; 2010's: OR=1.37, 95% CI: 1.22-1.56. In a random effects model: 1990's: OR=1.98, 95% CI: 1.08-3.62; 2000's: OR=1.64, 95% CI: 1.23-2.19; 2010's: OR=1.34, 95% CI: 1.03-1.73. Finally a meta-analysis stratified by each country was conducted. In fixed effect models, U.S: pooled OR =1.45, 95% CI: 1.34-1.57; China: pooled OR =4.67, 95% CI: 3.08-7.07; Cuba: pooled OR =1.43, 95% CI: 1.00-2.04; Italy: pooled OR =0.61, 95% CI: 0.13-2.90. In random effects model, U.S: pooled OR=1.50, 95% CI: 1.25-1.80; China: pooled OR =4.67, 95% CI: 3.08-7.07; Cuba: pooled OR =1.43, 95% CI: 1.00-2.04; Italy: pooled OR =0.61, 95% CI: 0.13-2.90. CONCLUSIONS: the present meta-analysis provides the statistical evidence that the association between prostatitis and prostate cancer is significant.
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U2 - 10.1371/journal.pone.0085179
DO - 10.1371/journal.pone.0085179
M3 - Article
C2 - 24391995
AN - SCOPUS:84894049683
SN - 1932-6203
VL - 8
JO - PloS one
JF - PloS one
IS - 12
M1 - e85179
ER -