The role of prostatitis in prostate cancer

Meta-analysis

Junyi Jiang, Jinyi Li, Yunxia Zhang, Hong Zhu, Junjiang Liu, Chris Pumill

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Objective: Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model. Evidence Acquisition: Case control studies of prostate cancer with information on prostatitis history. All studies published between 1990-2012, were collected to calculate a pooled odds ratio. Selection criteria: the selection criteria are as follows: human case control studies; published from May 1990 to July 2012; containing number of prostatitis, and prostate cancer cases. Evidence Synthesis: In total, 20 case control studies were included. A significant association between prostatitis and prostate cancer was found, under both fixed effect model (pooled OR=1.50, 95% CI: 1.39-1.62), and random effects model (OR=1.64, 95% CI: 1.36-1.98). Personal interview based case control studies showed a high level of association (fixed effect model: pooled OR=1.59, 95% CI: 1.47-1.73, random effects model: pooled OR= 1.87, 95% CI: 1.52-2.29), compared with clinical based studies (fixed effect model: pooled OR=1.05, 95% CI: 0.86-1.28, random effects model: pooled OR= 0.98, 95% CI: 0.67-1.45). Additionally, pooled ORs, were calculated for each decade. In a fixed effect model: 1990's: OR=1.58, 95% CI: 1.35-1.84; 2000's: OR=1.59, 95% CI: 1.40-1.79; 2010's: OR=1.37, 95% CI: 1.22-1.56. In a random effects model: 1990's: OR=1.98, 95% CI: 1.08-3.62; 2000's: OR=1.64, 95% CI: 1.23-2.19; 2010's: OR=1.34, 95% CI: 1.03-1.73. Finally a meta-analysis stratified by each country was conducted. In fixed effect models, U.S: pooled OR =1.45, 95% CI: 1.34-1.57; China: pooled OR =4.67, 95% CI: 3.08-7.07; Cuba: pooled OR =1.43, 95% CI: 1.00-2.04; Italy: pooled OR =0.61, 95% CI: 0.13-2.90. In random effects model, U.S: pooled OR=1.50, 95% CI: 1.25-1.80; China: pooled OR =4.67, 95% CI: 3.08-7.07; Cuba: pooled OR =1.43, 95% CI: 1.00-2.04; Italy: pooled OR =0.61, 95% CI: 0.13-2.90. CONCLUSIONS: the present meta-analysis provides the statistical evidence that the association between prostatitis and prostate cancer is significant.

Original languageEnglish (US)
Article numbere85179
JournalPLoS One
Volume8
Issue number12
DOIs
StatePublished - Dec 31 2013

Fingerprint

prostatitis
Prostatitis
prostatic neoplasms
meta-analysis
Meta-Analysis
Prostatic Neoplasms
Case-Control Studies
Cuba
Patient Selection
case-control studies
Italy
China
Association reactions
selection criteria
Odds Ratio
Interviews
systematic review
odds ratio
interviews

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Jiang, J., Li, J., Zhang, Y., Zhu, H., Liu, J., & Pumill, C. (2013). The role of prostatitis in prostate cancer: Meta-analysis. PLoS One, 8(12), [e85179]. https://doi.org/10.1371/journal.pone.0085179

The role of prostatitis in prostate cancer : Meta-analysis. / Jiang, Junyi; Li, Jinyi; Zhang, Yunxia; Zhu, Hong; Liu, Junjiang; Pumill, Chris.

In: PLoS One, Vol. 8, No. 12, e85179, 31.12.2013.

Research output: Contribution to journalArticle

Jiang, J, Li, J, Zhang, Y, Zhu, H, Liu, J & Pumill, C 2013, 'The role of prostatitis in prostate cancer: Meta-analysis', PLoS One, vol. 8, no. 12, e85179. https://doi.org/10.1371/journal.pone.0085179
Jiang, Junyi ; Li, Jinyi ; Zhang, Yunxia ; Zhu, Hong ; Liu, Junjiang ; Pumill, Chris. / The role of prostatitis in prostate cancer : Meta-analysis. In: PLoS One. 2013 ; Vol. 8, No. 12.
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title = "The role of prostatitis in prostate cancer: Meta-analysis",
abstract = "Objective: Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model. Evidence Acquisition: Case control studies of prostate cancer with information on prostatitis history. All studies published between 1990-2012, were collected to calculate a pooled odds ratio. Selection criteria: the selection criteria are as follows: human case control studies; published from May 1990 to July 2012; containing number of prostatitis, and prostate cancer cases. Evidence Synthesis: In total, 20 case control studies were included. A significant association between prostatitis and prostate cancer was found, under both fixed effect model (pooled OR=1.50, 95{\%} CI: 1.39-1.62), and random effects model (OR=1.64, 95{\%} CI: 1.36-1.98). Personal interview based case control studies showed a high level of association (fixed effect model: pooled OR=1.59, 95{\%} CI: 1.47-1.73, random effects model: pooled OR= 1.87, 95{\%} CI: 1.52-2.29), compared with clinical based studies (fixed effect model: pooled OR=1.05, 95{\%} CI: 0.86-1.28, random effects model: pooled OR= 0.98, 95{\%} CI: 0.67-1.45). Additionally, pooled ORs, were calculated for each decade. In a fixed effect model: 1990's: OR=1.58, 95{\%} CI: 1.35-1.84; 2000's: OR=1.59, 95{\%} CI: 1.40-1.79; 2010's: OR=1.37, 95{\%} CI: 1.22-1.56. In a random effects model: 1990's: OR=1.98, 95{\%} CI: 1.08-3.62; 2000's: OR=1.64, 95{\%} CI: 1.23-2.19; 2010's: OR=1.34, 95{\%} CI: 1.03-1.73. Finally a meta-analysis stratified by each country was conducted. In fixed effect models, U.S: pooled OR =1.45, 95{\%} CI: 1.34-1.57; China: pooled OR =4.67, 95{\%} CI: 3.08-7.07; Cuba: pooled OR =1.43, 95{\%} CI: 1.00-2.04; Italy: pooled OR =0.61, 95{\%} CI: 0.13-2.90. In random effects model, U.S: pooled OR=1.50, 95{\%} CI: 1.25-1.80; China: pooled OR =4.67, 95{\%} CI: 3.08-7.07; Cuba: pooled OR =1.43, 95{\%} CI: 1.00-2.04; Italy: pooled OR =0.61, 95{\%} CI: 0.13-2.90. CONCLUSIONS: the present meta-analysis provides the statistical evidence that the association between prostatitis and prostate cancer is significant.",
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AU - Jiang, Junyi

AU - Li, Jinyi

AU - Zhang, Yunxia

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AU - Pumill, Chris

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N2 - Objective: Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model. Evidence Acquisition: Case control studies of prostate cancer with information on prostatitis history. All studies published between 1990-2012, were collected to calculate a pooled odds ratio. Selection criteria: the selection criteria are as follows: human case control studies; published from May 1990 to July 2012; containing number of prostatitis, and prostate cancer cases. Evidence Synthesis: In total, 20 case control studies were included. A significant association between prostatitis and prostate cancer was found, under both fixed effect model (pooled OR=1.50, 95% CI: 1.39-1.62), and random effects model (OR=1.64, 95% CI: 1.36-1.98). Personal interview based case control studies showed a high level of association (fixed effect model: pooled OR=1.59, 95% CI: 1.47-1.73, random effects model: pooled OR= 1.87, 95% CI: 1.52-2.29), compared with clinical based studies (fixed effect model: pooled OR=1.05, 95% CI: 0.86-1.28, random effects model: pooled OR= 0.98, 95% CI: 0.67-1.45). Additionally, pooled ORs, were calculated for each decade. In a fixed effect model: 1990's: OR=1.58, 95% CI: 1.35-1.84; 2000's: OR=1.59, 95% CI: 1.40-1.79; 2010's: OR=1.37, 95% CI: 1.22-1.56. In a random effects model: 1990's: OR=1.98, 95% CI: 1.08-3.62; 2000's: OR=1.64, 95% CI: 1.23-2.19; 2010's: OR=1.34, 95% CI: 1.03-1.73. Finally a meta-analysis stratified by each country was conducted. In fixed effect models, U.S: pooled OR =1.45, 95% CI: 1.34-1.57; China: pooled OR =4.67, 95% CI: 3.08-7.07; Cuba: pooled OR =1.43, 95% CI: 1.00-2.04; Italy: pooled OR =0.61, 95% CI: 0.13-2.90. In random effects model, U.S: pooled OR=1.50, 95% CI: 1.25-1.80; China: pooled OR =4.67, 95% CI: 3.08-7.07; Cuba: pooled OR =1.43, 95% CI: 1.00-2.04; Italy: pooled OR =0.61, 95% CI: 0.13-2.90. CONCLUSIONS: the present meta-analysis provides the statistical evidence that the association between prostatitis and prostate cancer is significant.

AB - Objective: Use systematic review methods to quantify the association between prostatitis and prostate cancer, under both fixed and random effects model. Evidence Acquisition: Case control studies of prostate cancer with information on prostatitis history. All studies published between 1990-2012, were collected to calculate a pooled odds ratio. Selection criteria: the selection criteria are as follows: human case control studies; published from May 1990 to July 2012; containing number of prostatitis, and prostate cancer cases. Evidence Synthesis: In total, 20 case control studies were included. A significant association between prostatitis and prostate cancer was found, under both fixed effect model (pooled OR=1.50, 95% CI: 1.39-1.62), and random effects model (OR=1.64, 95% CI: 1.36-1.98). Personal interview based case control studies showed a high level of association (fixed effect model: pooled OR=1.59, 95% CI: 1.47-1.73, random effects model: pooled OR= 1.87, 95% CI: 1.52-2.29), compared with clinical based studies (fixed effect model: pooled OR=1.05, 95% CI: 0.86-1.28, random effects model: pooled OR= 0.98, 95% CI: 0.67-1.45). Additionally, pooled ORs, were calculated for each decade. In a fixed effect model: 1990's: OR=1.58, 95% CI: 1.35-1.84; 2000's: OR=1.59, 95% CI: 1.40-1.79; 2010's: OR=1.37, 95% CI: 1.22-1.56. In a random effects model: 1990's: OR=1.98, 95% CI: 1.08-3.62; 2000's: OR=1.64, 95% CI: 1.23-2.19; 2010's: OR=1.34, 95% CI: 1.03-1.73. Finally a meta-analysis stratified by each country was conducted. In fixed effect models, U.S: pooled OR =1.45, 95% CI: 1.34-1.57; China: pooled OR =4.67, 95% CI: 3.08-7.07; Cuba: pooled OR =1.43, 95% CI: 1.00-2.04; Italy: pooled OR =0.61, 95% CI: 0.13-2.90. In random effects model, U.S: pooled OR=1.50, 95% CI: 1.25-1.80; China: pooled OR =4.67, 95% CI: 3.08-7.07; Cuba: pooled OR =1.43, 95% CI: 1.00-2.04; Italy: pooled OR =0.61, 95% CI: 0.13-2.90. CONCLUSIONS: the present meta-analysis provides the statistical evidence that the association between prostatitis and prostate cancer is significant.

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