All calciotropic hormones have vasculotropic actions. This terse tenet challenges us to re-think the roles played by the PTH/PTHrP receptor (PTH1R) in vertebrate physiology. PTH1R signaling does not only control bone formation and serum calcium phosphate homeostasis. Cues dependent upon the PTH1R maintain myocardial viability during prenatal development and regulate arteriosclerotic calcification and vascular remodeling during post-natal life. A better understanding of the mechanisms whereby PTH/PTHrP signaling impacts the cardiovascular system will provide therapeutic insights useful for treating patients afflicted with heart failure, chronic kidney disease-mineral and bone disorder, and diabetic arteriosclerosis.
- Cardiovascular endocrinology
- Intracrine signaling
- Paracrine signaling
- Parathyroid hormone-related polypeptide
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Orthopedics and Sports Medicine