The role of PTHrP in vascular smooth muscle

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

All calciotropic hormones have vasculotropic actions. This terse tenet challenges us to re-think the roles played by the PTH/PTHrP receptor (PTH1R) in vertebrate physiology. PTH1R signaling does not only control bone formation and serum calcium phosphate homeostasis. Cues dependent upon the PTH1R maintain myocardial viability during prenatal development and regulate arteriosclerotic calcification and vascular remodeling during post-natal life. A better understanding of the mechanisms whereby PTH/PTHrP signaling impacts the cardiovascular system will provide therapeutic insights useful for treating patients afflicted with heart failure, chronic kidney disease-mineral and bone disorder, and diabetic arteriosclerosis.

Original languageEnglish (US)
Pages (from-to)190-196
Number of pages7
JournalClinical Reviews in Bone and Mineral Metabolism
Volume12
Issue number3
DOIs
StatePublished - Sep 2014

Keywords

  • Arteriosclerosis
  • Cardiovascular endocrinology
  • Intracrine signaling
  • P27Kip1
  • Paracrine signaling
  • Parathyroid hormone-related polypeptide

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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