The role of SAP and the SLAM family in autoimmunity

Alice Y. Chan, Jill M. Westcott, Jill M. Mooney, Edward K. Wakeland, John D. Schatzle

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

The signaling lymphocyte activation molecule (SLAM) family of receptors and their associated signaling adaptors play a pivotal role in the regulation of various stages of cellular immunity. They regulate lymphocyte-lymphocyte interactions involved in both cell-mediated and humoral immune responses. Recent evidence indicates that members of this family of receptors and signaling intermediates are also involved in autoimmunity. These include strictly correlative studies showing increased expression of various family members in immune effectors involved in rheumatoid arthritis and in inflammatory bowel disease, as well as more direct evidence (from various knockout strains of mice) for their role in autoimmune processes such as experimental allergic encephalomyelitis and lupus. Additional studies defining naturally occurring polymorphic variations in the SLAM family show a direct role in initiating the break in tolerance that is an essential step in the progression towards autoimmunity.

Original languageEnglish (US)
Pages (from-to)656-664
Number of pages9
JournalCurrent Opinion in Immunology
Volume18
Issue number6
DOIs
StatePublished - Dec 2006

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Lymphocyte Activation
Autoimmunity
Lymphocytes
Autoimmune Experimental Encephalomyelitis
Humoral Immunity
Inflammatory Bowel Diseases
Knockout Mice
Cellular Immunity
Rheumatoid Arthritis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

The role of SAP and the SLAM family in autoimmunity. / Chan, Alice Y.; Westcott, Jill M.; Mooney, Jill M.; Wakeland, Edward K.; Schatzle, John D.

In: Current Opinion in Immunology, Vol. 18, No. 6, 12.2006, p. 656-664.

Research output: Contribution to journalArticle

Chan, AY, Westcott, JM, Mooney, JM, Wakeland, EK & Schatzle, JD 2006, 'The role of SAP and the SLAM family in autoimmunity', Current Opinion in Immunology, vol. 18, no. 6, pp. 656-664. https://doi.org/10.1016/j.coi.2006.09.010
Chan, Alice Y. ; Westcott, Jill M. ; Mooney, Jill M. ; Wakeland, Edward K. ; Schatzle, John D. / The role of SAP and the SLAM family in autoimmunity. In: Current Opinion in Immunology. 2006 ; Vol. 18, No. 6. pp. 656-664.
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