The Role of Spinal Manipulation in Modifying Central Sensitization

Research output: Contribution to journalArticle

3 Scopus citations


Central sensitization (CS) is characterized by adaptations to the central nervous system resulting in decreased sensory thresholds and widespread hypersensitivity. CS is often difficult to manage, with current treatment strategies primarily consisting of medication, pain science education, cognitive behavioral therapy, and graded exercise intervention. Spinal manipulation represents a potential alternative treatment for CS because of its centrally acting neurophysiological mechanisms. However, experimental trials utilizing spinal manipulation in persons with CS often lack the controls or methodology required to determine the technique's effect on meaningful clinical outcomes. This paper summarizes the mechanistic and experimental evidence on spinal manipulation for centrally mediated pain and hypersensitivity, and offers recommendations for future study considerations in this topic area.

Original languageEnglish (US)
Pages (from-to)84-99
Number of pages16
JournalJournal of Applied Biobehavioral Research
Issue number2
StatePublished - Jun 1 2015

ASJC Scopus subject areas

  • Social Sciences (miscellaneous)
  • Clinical Psychology
  • Experimental and Cognitive Psychology
  • Cultural Studies

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