The role of the actin cytoskeleton in regulating Drosophila behavior

Shamsideen A. Ojelade, Summer F. Acevedo, Adrian Rothenfluh

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Over the past decade, the function of the cytoskeleton has been studied extensively in developing and mature neurons. Actin, a major cytoskeletal protein, is indispensable for the structural integrity and plasticity of neurons and their synapses. Disruption of actin dynamics has significant consequence for neurons, neuronal circuits, and the functions they govern. In particular, cell adhesion molecules, members of the Rho family of GTPases, and actin-binding proteins are important modulators of actin dynamics and neuronal as well as behavioral plasticity. In this review, we discuss recent advances in Drosophila that highlight the importance of actin regulatory proteins in mediating fly behaviors such as circadian rhythm, courtship behavior, learning and memory, and the development of drug addiction.

Original languageEnglish (US)
Pages (from-to)471-484
Number of pages14
JournalReviews in the Neurosciences
Volume24
Issue number5
DOIs
StatePublished - Oct 2013

Fingerprint

Actin Cytoskeleton
Drosophila
Actins
Neurons
Courtship
Microfilament Proteins
rho GTP-Binding Proteins
Cytoskeletal Proteins
Cell Adhesion Molecules
Circadian Rhythm
Cytoskeleton
Diptera
Synapses
Substance-Related Disorders
Learning
Proteins

Keywords

  • Actin
  • Behavior
  • Drosophila
  • Genetics

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The role of the actin cytoskeleton in regulating Drosophila behavior. / Ojelade, Shamsideen A.; Acevedo, Summer F.; Rothenfluh, Adrian.

In: Reviews in the Neurosciences, Vol. 24, No. 5, 10.2013, p. 471-484.

Research output: Contribution to journalArticle

Ojelade, Shamsideen A. ; Acevedo, Summer F. ; Rothenfluh, Adrian. / The role of the actin cytoskeleton in regulating Drosophila behavior. In: Reviews in the Neurosciences. 2013 ; Vol. 24, No. 5. pp. 471-484.
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