The role of the FOXP family of transcription factors in ASD

J. Michael Bowers, Genevieve Konopka

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Autism spectrum disorders (ASD) is a neurodevelopmental disease with complex genetics; however, the genes that are responsible for this disease still remain mostly unknown. Here, we focus on the FOXP family of transcription factors as there is emerging evidence strongly linking these genes to ASD and other genes implicated in ASD. The FOXP family of genes includes three genes expressed in the central nervous system: FOXP1, FOPX2, and FOXP4. This unique group of transcription factors has known functions in brain development as well as the evolution of language. We will also discuss the other genes including transcriptional targets of FOXP genes that have been found to be associated with language and may be important in the pathophysiology of ASD. Finally, we will review the emerging animal models currently being used to study the function of the FOXP genes within the context of ASD symptomology. The combination of gene expression and animal behavior is critical for elucidating how genes such as the FOXP family members are key players within the framework of the developing brain.

Original languageEnglish (US)
Pages (from-to)251-260
Number of pages10
JournalDisease Markers
Volume33
Issue number5
DOIs
StatePublished - 2012

Fingerprint

Transcription Factors
Genes
Brain
Animals
Language
Autism Spectrum Disorder
Animal Behavior
Neurology
Gene expression
Central Nervous System
Animal Models
Gene Expression

Keywords

  • autism
  • FOXP1
  • FOXP2
  • genetics

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

Cite this

The role of the FOXP family of transcription factors in ASD. / Bowers, J. Michael; Konopka, Genevieve.

In: Disease Markers, Vol. 33, No. 5, 2012, p. 251-260.

Research output: Contribution to journalArticle

Bowers, J. Michael ; Konopka, Genevieve. / The role of the FOXP family of transcription factors in ASD. In: Disease Markers. 2012 ; Vol. 33, No. 5. pp. 251-260.
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