TY - JOUR
T1 - The role of the immune system in glaucoma
T2 - Bridging the divide between immune mechanisms in experimental glaucoma and the human disease
AU - Kamat, Shivani S.
AU - Gregory, Meredith S.
AU - Pasquale, Louis R.
N1 - Publisher Copyright:
© 2016 Taylor & Francis.
PY - 2016/3/3
Y1 - 2016/3/3
N2 - Glaucoma is one of the leading causes of visual impairment worldwide. Classically, clinicians have evaluated patients through a full ophthalmological examination including gonioscopy, measurement of intraocular pressure (IOP), and assessment of the optic nerve. New imaging modalities have further enhanced our ability to evaluate glaucoma; however, our treatments have not evolved as much. Whether one uses medical treatment with topical ocular antihypertensives, laser trabeculoplasty, or filtering surgery, the mainstay of treatment is to lower IOP. However, as our understanding of the disease evolves, mechanisms other than elevated IOP have been implicated in glaucoma pathogenesis. Recent animal model studies have shown a possible role of the immune system in the pathophysiology of glaucoma. This article explores the current understanding of immune reactions in glaucoma, which could lead to a new paradigm of treatment for human disease.
AB - Glaucoma is one of the leading causes of visual impairment worldwide. Classically, clinicians have evaluated patients through a full ophthalmological examination including gonioscopy, measurement of intraocular pressure (IOP), and assessment of the optic nerve. New imaging modalities have further enhanced our ability to evaluate glaucoma; however, our treatments have not evolved as much. Whether one uses medical treatment with topical ocular antihypertensives, laser trabeculoplasty, or filtering surgery, the mainstay of treatment is to lower IOP. However, as our understanding of the disease evolves, mechanisms other than elevated IOP have been implicated in glaucoma pathogenesis. Recent animal model studies have shown a possible role of the immune system in the pathophysiology of glaucoma. This article explores the current understanding of immune reactions in glaucoma, which could lead to a new paradigm of treatment for human disease.
KW - Adaptive immunity
KW - Glaucoma
KW - Innate immunity
KW - TNF alpha
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U2 - 10.3109/08820538.2015.1114858
DO - 10.3109/08820538.2015.1114858
M3 - Review article
C2 - 26959140
AN - SCOPUS:84962155987
SN - 0882-0538
VL - 31
SP - 147
EP - 154
JO - Seminars in Ophthalmology
JF - Seminars in Ophthalmology
IS - 1-2
ER -