The role of the programmed death receptor-1/programmed death ligand-1: Immunologic checkpoint in human papillomavirus-Associated head and neck squamous cell carcinoma

Christine Kunkle, Flavia G. Rosado

Research output: Contribution to journalArticle

Abstract

Context.-There has been increasing interest in understanding the role of programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) pathway in cancer biology and its clinical significance in cancer therapy. Objective.-To discuss the studies of the PD-1/PD-L1 pathway in human papillomavirus-positive head and neck squamous cell carcinoma, focusing on the pathogenesis of cancer, characterization of the tumor microenvironment and the effect of such studies in laboratory medicine. Data sources.-Data sources included peer-reviewed literature and reputable online sources. Conclusions.-To date, there are few studies of PD-1 and PD-L1 in human papillomavirus-positive head and neck squamous cell carcinoma. There is evidence that the PD-1/PD-L1 pathway has a role in this type of cancer; however, further studies are needed to better characterize the effect of the human papillomavirus and its use as a marker of therapy response.

Original languageEnglish (US)
Pages (from-to)719-720
Number of pages2
JournalArchives of Pathology and Laboratory Medicine
Volume142
Issue number6
DOIs
StatePublished - Jun 2018
Externally publishedYes

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Death Domain Receptors
Ligands
Information Storage and Retrieval
Neoplasms
Tumor Microenvironment
Medicine
Carcinoma, squamous cell of head and neck
Therapeutics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

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abstract = "Context.-There has been increasing interest in understanding the role of programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) pathway in cancer biology and its clinical significance in cancer therapy. Objective.-To discuss the studies of the PD-1/PD-L1 pathway in human papillomavirus-positive head and neck squamous cell carcinoma, focusing on the pathogenesis of cancer, characterization of the tumor microenvironment and the effect of such studies in laboratory medicine. Data sources.-Data sources included peer-reviewed literature and reputable online sources. Conclusions.-To date, there are few studies of PD-1 and PD-L1 in human papillomavirus-positive head and neck squamous cell carcinoma. There is evidence that the PD-1/PD-L1 pathway has a role in this type of cancer; however, further studies are needed to better characterize the effect of the human papillomavirus and its use as a marker of therapy response.",
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