The role of ubiquitin in NF-κB regulatory pathways

Brian Skaug, Xiaomo Jiang, Zhijian J. Chen

Research output: Contribution to journalArticle

346 Citations (Scopus)

Abstract

Nuclear factor kappa enhancer binding protein (NF-κB) regulates diverse biological processes including immunity, inflammation, and apoptosis. A vast array of cellular stimuli converges on NF-κB, and ubiquitination plays an essential role in the coordination of these signals to regulate NF-κB activity. At least three steps in NF-κB activation directly involve ubiquitination: proteasomal degradation of inhibitor of NF-κB (IκB), processing of NF-κB precursors, and activation of the transforming growth factor (TGF)-β-activated kinase (TAK1) and IκB kinase (IKK) complexes. In this review, we discuss recent advances in the identification and characterization of ubiquitination and deubiquitination machinery that regulate NF-κB. Particular emphasis is given to proteasome-independent functions of ubiquitin, specifically its role in the activation of protein kinase complexes and in coordination of cell survival and apoptosis signals downstream of tumor necrosis factor α (TNFα).

Original languageEnglish (US)
Pages (from-to)769-796
Number of pages28
JournalAnnual Review of Biochemistry
Volume78
DOIs
StatePublished - 2009

Fingerprint

Ubiquitination
Ubiquitin
Chemical activation
Phosphotransferases
Apoptosis
Biological Phenomena
NF-kappa B
Coordination Complexes
Transforming Growth Factors
Corrosion inhibitors
Proteasome Endopeptidase Complex
Protein Kinases
Machinery
Immunity
Cell Survival
Carrier Proteins
Tumor Necrosis Factor-alpha
Cells
Inflammation
Degradation

Keywords

  • Apoptosis
  • Deubiquitination
  • IKK
  • TAK1

ASJC Scopus subject areas

  • Biochemistry

Cite this

The role of ubiquitin in NF-κB regulatory pathways. / Skaug, Brian; Jiang, Xiaomo; Chen, Zhijian J.

In: Annual Review of Biochemistry, Vol. 78, 2009, p. 769-796.

Research output: Contribution to journalArticle

Skaug, Brian ; Jiang, Xiaomo ; Chen, Zhijian J. / The role of ubiquitin in NF-κB regulatory pathways. In: Annual Review of Biochemistry. 2009 ; Vol. 78. pp. 769-796.
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