The role of ubiquitylation in immune defence and pathogen evasion

Xiaomo Jiang, Zhijian J. Chen

Research output: Contribution to journalReview articlepeer-review

186 Scopus citations

Abstract

Ubiquitylation is a widely used post-translational protein modification that regulates many biological processes, including immune responses. The role of ubiquitin in immune regulation was originally uncovered through studies of antigen presentation and the nuclear factor-κB family of transcription factors, which orchestrate host defence against microorganisms. Recent studies have revealed crucial roles of ubiquitylation in many aspects of the immune system, including innate and adaptive immunity and antimicrobial autophagy. In addition, mounting evidence indicates that microbial pathogens exploit the ubiquitin pathway to evade the host immune system. Here, we review recent advances on the role of ubiquitylation in host defence and pathogen evasion.

Original languageEnglish (US)
Pages (from-to)35-48
Number of pages14
JournalNature Reviews Immunology
Volume12
Issue number1
DOIs
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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