The role of ubiquitylation in immune defence and pathogen evasion

Xiaomo Jiang, Zhijian J. Chen

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

Ubiquitylation is a widely used post-translational protein modification that regulates many biological processes, including immune responses. The role of ubiquitin in immune regulation was originally uncovered through studies of antigen presentation and the nuclear factor-κB family of transcription factors, which orchestrate host defence against microorganisms. Recent studies have revealed crucial roles of ubiquitylation in many aspects of the immune system, including innate and adaptive immunity and antimicrobial autophagy. In addition, mounting evidence indicates that microbial pathogens exploit the ubiquitin pathway to evade the host immune system. Here, we review recent advances on the role of ubiquitylation in host defence and pathogen evasion.

Original languageEnglish (US)
Pages (from-to)35-48
Number of pages14
JournalNature Reviews Immunology
Volume12
Issue number1
DOIs
StatePublished - Jan 2012

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Ubiquitination
Ubiquitin
Immune System
Biological Phenomena
Autophagy
Antigen Presentation
Adaptive Immunity
Post Translational Protein Processing
Innate Immunity
Transcription Factors

ASJC Scopus subject areas

  • Immunology

Cite this

The role of ubiquitylation in immune defence and pathogen evasion. / Jiang, Xiaomo; Chen, Zhijian J.

In: Nature Reviews Immunology, Vol. 12, No. 1, 01.2012, p. 35-48.

Research output: Contribution to journalArticle

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