The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer

Xijuan Liu, Giada Zurlo, Qing Zhang

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Posttranslational protein modifications play an important role in regulating protein stability and cellular function. There are at least eight Cullin family members. Among them, Cullin-2 forms a functional E3 ligase complex with elongin B, elongin C, RING-box protein 1 (RBX1, also called ROC1), as well as the substrate recognition subunit (SRS) to promote the substrate ubiquitination and degradation. In this book chapter, we will review Cullin-2 E3 ligase complexes that include various SRS proteins, including von Hippel Lindau (pVHL), leucine-rich repeat protein-1 (LRR-1), preferentially expressed antigen of melanoma (PRAME), sex-determining protein FEM-1 and early embryogenesis protein ZYG-11. We will focus on the VHL signaling pathway in clear cell renal cell carcinoma (ccRCC), which may reveal various therapeutic avenues in treating this lethal cancer.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages173-186
Number of pages14
DOIs
StatePublished - Jan 1 2020

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1217
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cancer
  • ccRCC
  • Cullin-2
  • E3 ubiquitin ligase
  • HIF
  • Hypoxia
  • pVHL
  • VHL

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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