The roles of DNA topoisomerase IIβ in transcription

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Type IIA topoisomerases allow DNA double helical strands to pass through each other by generating transient DNA double strand breaks βDSBs), and in so doing, resolve torsional strain that accumulates during transcription, DNA replication, chromosome condensation, chromosome segregation and recombination. Whereas most eukaryotes possess a single type IIA enzyme, vertebrates possess two distinct type IIA topoisomerases, Topo IIα and Topo IIβ. Although the roles of Topo IIα, especially in the context of chromosome condensation and segregation, have been well-studied, the roles of Topo IIβ are only beginning to be illuminated. This review begins with a summary of the initial studies surrounding the discovery and characterization of Topo IIβ and then focuses on the insights gained from more recent studies that have elaborated important functions for Topo IIβ in transcriptional regulation.

Original languageEnglish (US)
Article number1917
JournalInternational Journal of Molecular Sciences
Volume19
Issue number7
DOIs
StatePublished - Jul 1 2018

Fingerprint

Type II DNA Topoisomerase
Chromosome Segregation
chromosomes
Transcription
Chromosomes
DNA
DNA Topoisomerases
deoxyribonucleic acid
strands
Double-Stranded DNA Breaks
Condensation
condensation
Eukaryota
DNA Replication
eukaryotes
Genetic Recombination
Vertebrates
vertebrates
enzymes
Enzymes

Keywords

  • DNA double strand breaks
  • DNA topoisomerase
  • Topology
  • Transcription

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

Cite this

The roles of DNA topoisomerase IIβ in transcription. / Madabhushi, Ram.

In: International Journal of Molecular Sciences, Vol. 19, No. 7, 1917, 01.07.2018.

Research output: Contribution to journalReview article

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