Abstract
The aim of this study was to construct bispecific F(ab')2 [anti-CD3 x anti-BCL1 idiotype (Id)]Abs (BsAbs) which would enable lymphokine-activated killer (LAK) T cells to kill Id+ mouse BCL1 lymphoma cells, and to determine the mechanism(s) underlying cell death. Using 4-day activated LAK T cells from either perforin-knockout mice or FasL-deficient gld mice, we show that the Fas pathway, but not perforin, is required for BsAb-mediated LAK T-cell-induced killing of BCL1 cells.
Original language | English (US) |
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Pages (from-to) | 822-827 |
Number of pages | 6 |
Journal | International Journal of Cancer |
Volume | 68 |
Issue number | 6 |
DOIs | |
State | Published - Dec 11 1996 |
ASJC Scopus subject areas
- Oncology
- Cancer Research