The roles of Fas and perforin in LAK T-cell/bispecific antibody-mediated killing of the murine B-lymphoma cells, BCL1

John M. Armstrong, Ellen S. Vitetta

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

The aim of this study was to construct bispecific F(ab')2 [anti-CD3 x anti-BCL1 idiotype (Id)]Abs (BsAbs) which would enable lymphokine-activated killer (LAK) T cells to kill Id+ mouse BCL1 lymphoma cells, and to determine the mechanism(s) underlying cell death. Using 4-day activated LAK T cells from either perforin-knockout mice or FasL-deficient gld mice, we show that the Fas pathway, but not perforin, is required for BsAb-mediated LAK T-cell-induced killing of BCL1 cells.

Original languageEnglish (US)
Pages (from-to)822-827
Number of pages6
JournalInternational Journal of Cancer
Volume68
Issue number6
DOIs
StatePublished - Dec 11 1996

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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