The roles of Fas and perforin in LAK T-cell/bispecific antibody-mediated killing of the murine B-lymphoma cells, BCL1

John M. Armstrong, Ellen S. Vitetta

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The aim of this study was to construct bispecific F(ab')2 [anti-CD3 x anti-BCL1 idiotype (Id)]Abs (BsAbs) which would enable lymphokine-activated killer (LAK) T cells to kill Id+ mouse BCL1 lymphoma cells, and to determine the mechanism(s) underlying cell death. Using 4-day activated LAK T cells from either perforin-knockout mice or FasL-deficient gld mice, we show that the Fas pathway, but not perforin, is required for BsAb-mediated LAK T-cell-induced killing of BCL1 cells.

Original languageEnglish (US)
Pages (from-to)822-827
Number of pages6
JournalInternational Journal of Cancer
Volume68
Issue number6
DOIs
StatePublished - Dec 11 1996

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Bispecific Antibodies
Lymphokine-Activated Killer Cells
Perforin
B-Cell Lymphoma
T-Lymphocytes
Knockout Mice
Lymphoma
Cell Death

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

The roles of Fas and perforin in LAK T-cell/bispecific antibody-mediated killing of the murine B-lymphoma cells, BCL1 . / Armstrong, John M.; Vitetta, Ellen S.

In: International Journal of Cancer, Vol. 68, No. 6, 11.12.1996, p. 822-827.

Research output: Contribution to journalArticle

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