TY - JOUR
T1 - The running wheel enhances food anticipatory activity
T2 - An exploratory study
AU - Flôres, Danilo E F L
AU - Bettilyon, Crystal N.
AU - Jia, Lori
AU - Yamazaki, Shin
N1 - Publisher Copyright:
© 2016 Flôres, Bettilyon, Jia and Yamazaki.
PY - 2016/7/5
Y1 - 2016/7/5
N2 - Rodents anticipate rewarding stimuli such as daily meals, mates, and stimulant drugs. When a single meal is provided daily at a fixed time of day, an increase in activity, known as food anticipatory activity (FAA), occurs several hours before feeding time. The factors affecting the expression of FAA have not been well-studied. Understanding these factors may provide clues to the undiscovered anatomical substrates of food entrainment. In this study we determined whether wheel-running activity, which is also rewarding to rodents, modulated the robustness of FAA. We found that access to a freely rotating wheel enhanced the robustness of FAA. This enhancement was lost when the wheel was removed. In addition, while prior exposure to a running wheel alone did not enhance FAA, the presence of a locked wheel did enhance FAA as long as mice had previously run in the wheel. Together, these data suggest that FAA, like wheel-running activity, is influenced by reward signaling.
AB - Rodents anticipate rewarding stimuli such as daily meals, mates, and stimulant drugs. When a single meal is provided daily at a fixed time of day, an increase in activity, known as food anticipatory activity (FAA), occurs several hours before feeding time. The factors affecting the expression of FAA have not been well-studied. Understanding these factors may provide clues to the undiscovered anatomical substrates of food entrainment. In this study we determined whether wheel-running activity, which is also rewarding to rodents, modulated the robustness of FAA. We found that access to a freely rotating wheel enhanced the robustness of FAA. This enhancement was lost when the wheel was removed. In addition, while prior exposure to a running wheel alone did not enhance FAA, the presence of a locked wheel did enhance FAA as long as mice had previously run in the wheel. Together, these data suggest that FAA, like wheel-running activity, is influenced by reward signaling.
KW - Circadian
KW - Food-entrainable oscillator
KW - Mouse
KW - Restricted feeding
KW - Reward
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U2 - 10.3389/fnbeh.2016.00143
DO - 10.3389/fnbeh.2016.00143
M3 - Article
C2 - 27458354
AN - SCOPUS:84978732521
SN - 1662-5153
VL - 10
JO - Frontiers in Behavioral Neuroscience
JF - Frontiers in Behavioral Neuroscience
IS - JULY
M1 - 143
ER -