The running wheel enhances food anticipatory activity: An exploratory study

Danilo E F L Flôres, Crystal N. Bettilyon, Lori Jia, Shin Yamazaki

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Rodents anticipate rewarding stimuli such as daily meals, mates, and stimulant drugs. When a single meal is provided daily at a fixed time of day, an increase in activity, known as food anticipatory activity (FAA), occurs several hours before feeding time. The factors affecting the expression of FAA have not been well-studied. Understanding these factors may provide clues to the undiscovered anatomical substrates of food entrainment. In this study we determined whether wheel-running activity, which is also rewarding to rodents, modulated the robustness of FAA. We found that access to a freely rotating wheel enhanced the robustness of FAA. This enhancement was lost when the wheel was removed. In addition, while prior exposure to a running wheel alone did not enhance FAA, the presence of a locked wheel did enhance FAA as long as mice had previously run in the wheel. Together, these data suggest that FAA, like wheel-running activity, is influenced by reward signaling.

Original languageEnglish (US)
Article number143
JournalFrontiers in Behavioral Neuroscience
Volume10
Issue numberJULY
DOIs
Publication statusPublished - Jul 5 2016

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Keywords

  • Circadian
  • Food-entrainable oscillator
  • Mouse
  • Restricted feeding
  • Reward

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

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