The Saitohin 'Q7R' polymorphism and tau haplotype in multi-ethnic Alzheimer disease and Parkinson's disease cohorts

Lorraine N. Clark, Gilberto Levy, Ming Xin Tang, Helen Mejia-Santana, Alejandra Ciappa, Benjamin Tycko, Lucien J. Cote, Elan D. Louis, Richard Mayeux, Karen Marder

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

In a multi-ethnic cohort we analyzed the Saitohin (STH) gene 'Q7R' polymorphism in 200 late-onset Alzheimer's disease cases (LOAD), 60 Parkinson's disease cases with dementia (PDD), 84 Parkinson's disease cases without dementia and 458 controls. We found no significant differences in genotype or allele frequencies when LOAD or PD cases were compared to controls. Ethnic differences in STH genotype frequencies for cases and controls were observed and these were statistically significant (cases n=344, P<0.03; controls n=458, P<0.001). We also observed a trend in non-Hispanic white PDD cases with the STH 'QQ' (Tau H1/H1) genotype increased (76%) compared to PD cases without dementia (61.7%) and controls (56.6%); however, this difference was not statistically significant (PDD vs. controls OR 2.1; 95% CI: 0.8-5.8, P=0.2).

Original languageEnglish (US)
Pages (from-to)17-20
Number of pages4
JournalNeuroscience letters
Volume347
Issue number1
DOIs
StatePublished - Aug 14 2003
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Case-control study
  • Multi-ethnic
  • Parkinson's disease
  • Parkinson's disease with dementia
  • Saitohin
  • Tau haplotype

ASJC Scopus subject areas

  • Neuroscience(all)

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