The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes

Yasushi Uematsu, Kirsten FischerLindahl, Michael Steinmetz

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the Aβ2gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/Aβ3and Aβ3/Aβ2recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.

Original languageEnglish (US)
Pages (from-to)96-101
Number of pages6
JournalImmunogenetics
Volume27
Issue number2
DOIs
StatePublished - Feb 1988

Fingerprint

Major Histocompatibility Complex
Haplotypes
Chromosomes
Southern Blotting

ASJC Scopus subject areas

  • Immunology
  • Genetics

Cite this

The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes. / Uematsu, Yasushi; FischerLindahl, Kirsten; Steinmetz, Michael.

In: Immunogenetics, Vol. 27, No. 2, 02.1988, p. 96-101.

Research output: Contribution to journalArticle

Uematsu, Yasushi ; FischerLindahl, Kirsten ; Steinmetz, Michael. / The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes. In: Immunogenetics. 1988 ; Vol. 27, No. 2. pp. 96-101.
@article{2c265f919c5a4d02ac44b382f9d99990,
title = "The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes",
abstract = "Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the Aβ2gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/Aβ3and Aβ3/Aβ2recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.",
author = "Yasushi Uematsu and Kirsten FischerLindahl and Michael Steinmetz",
year = "1988",
month = "2",
doi = "10.1007/BF00351082",
language = "English (US)",
volume = "27",
pages = "96--101",
journal = "Immunogenetics",
issn = "0093-7711",
publisher = "Springer Verlag",
number = "2",

}

TY - JOUR

T1 - The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes

AU - Uematsu, Yasushi

AU - FischerLindahl, Kirsten

AU - Steinmetz, Michael

PY - 1988/2

Y1 - 1988/2

N2 - Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the Aβ2gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/Aβ3and Aβ3/Aβ2recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.

AB - Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the Aβ2gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/Aβ3and Aβ3/Aβ2recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.

UR - http://www.scopus.com/inward/record.url?scp=0023833868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023833868&partnerID=8YFLogxK

U2 - 10.1007/BF00351082

DO - 10.1007/BF00351082

M3 - Article

C2 - 2891614

AN - SCOPUS:0023833868

VL - 27

SP - 96

EP - 101

JO - Immunogenetics

JF - Immunogenetics

SN - 0093-7711

IS - 2

ER -