The SCAP/SREBP pathway: A mediator of hepatic steatosis

Young Ah Moon

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Nonalcoholic fatty liver disease (NAFLD) is strongly associated with insulin resistance, obesity, and dyslipidemia. NAFLD encompasses a wide range of states from the simple accumulation of triglycerides in the hepatocytes to serious states accompanied by inflammation and fibrosis in the liver. De novo lipogenesis has been shown to be a significant factor in the development of hepatic steatosis in insulin-resistant states. Sterol regulatory element binding protein-1c (SREBP-1c) is the main transcription factor that mediates the activation of lipogenesis, and SREBP cleavage activating protein (SCAP) is required for the activation of SREBPs. Here, recent animal studies that suggest SCAP as a therapeutic target for hepatic steatosis and hypertriglyceridemia are discussed.

Original languageEnglish (US)
Pages (from-to)6-10
Number of pages5
JournalEndocrinology and Metabolism
Volume32
Issue number1
DOIs
StatePublished - Mar 1 2017

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Keywords

  • Hypertriglyceridemia
  • Insulin resistance
  • Lipogenesis
  • Non-alcoholic fatty liver disease

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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