The school inner-city Asthma study

Design, methods, and lessons learned

Wanda Phipatanakul, Anne Bailey, Elaine B. Hoffman, William J. Sheehan, Jeffrey P. Lane, Sachin Baxi, Devika Rao, Perdita Permaul, Jonathan M. Gaffin, Christine A. Rogers, Michael L. Muilenberg, Diane R. Gold

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background. Children spend a significant amount of time in school. Little is known about the role of allergen exposure in school environments and asthma morbidity. Objectives. The School Inner-City Asthma Study (SICAS) is a National Institutes of Health (NIH)-funded prospective study evaluating the school/classroom-specific risk factors and asthma morbidity among urban children. Methods/results. This article describes the design, methods, and important lessons learned from this extensive investigation. A single center is recruiting 500 elementary school-aged children, all of whom attend inner-city metropolitan schools. The primary hypothesis is that exposure to common indoor allergens in the classroom will increase the risk of asthma morbidity in children with asthma, even after controlling for home allergen exposures. The protocol includes screening surveys of entire schools and baseline eligibility assessments obtained in the spring prior to the academic year. Extensive baseline clinical visits are being conducted among eligible children with asthma during the summer prior to the academic school year. Environmental classroom/school assessments including settled dust and air sampling for allergen, mold, air pollution, and inspection data are collected twice during the academic school year and one home dust sample linked to the enrolled student. Clinical outcomes are measured every 3 months during the academic school year. Conclusion. The overall goal of SICAS is to complete the first study of its kind to better understand school-specific urban environmental factors on childhood asthma morbidity. We also discuss the unique challenges related to school-based urban research and lessons being learned from recruiting such a cohort.

Original languageEnglish (US)
Pages (from-to)1007-1014
Number of pages8
JournalJournal of Asthma
Volume48
Issue number10
DOIs
StatePublished - Dec 2011

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Asthma
Allergens
Morbidity
Dust
Air Pollution
National Institutes of Health (U.S.)
Fungi
Air
Prospective Studies
Students

Keywords

  • Asthma
  • Inner-city
  • School

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health

Cite this

Phipatanakul, W., Bailey, A., Hoffman, E. B., Sheehan, W. J., Lane, J. P., Baxi, S., ... Gold, D. R. (2011). The school inner-city Asthma study: Design, methods, and lessons learned. Journal of Asthma, 48(10), 1007-1014. https://doi.org/10.3109/02770903.2011.624235

The school inner-city Asthma study : Design, methods, and lessons learned. / Phipatanakul, Wanda; Bailey, Anne; Hoffman, Elaine B.; Sheehan, William J.; Lane, Jeffrey P.; Baxi, Sachin; Rao, Devika; Permaul, Perdita; Gaffin, Jonathan M.; Rogers, Christine A.; Muilenberg, Michael L.; Gold, Diane R.

In: Journal of Asthma, Vol. 48, No. 10, 12.2011, p. 1007-1014.

Research output: Contribution to journalArticle

Phipatanakul, W, Bailey, A, Hoffman, EB, Sheehan, WJ, Lane, JP, Baxi, S, Rao, D, Permaul, P, Gaffin, JM, Rogers, CA, Muilenberg, ML & Gold, DR 2011, 'The school inner-city Asthma study: Design, methods, and lessons learned', Journal of Asthma, vol. 48, no. 10, pp. 1007-1014. https://doi.org/10.3109/02770903.2011.624235
Phipatanakul W, Bailey A, Hoffman EB, Sheehan WJ, Lane JP, Baxi S et al. The school inner-city Asthma study: Design, methods, and lessons learned. Journal of Asthma. 2011 Dec;48(10):1007-1014. https://doi.org/10.3109/02770903.2011.624235
Phipatanakul, Wanda ; Bailey, Anne ; Hoffman, Elaine B. ; Sheehan, William J. ; Lane, Jeffrey P. ; Baxi, Sachin ; Rao, Devika ; Permaul, Perdita ; Gaffin, Jonathan M. ; Rogers, Christine A. ; Muilenberg, Michael L. ; Gold, Diane R. / The school inner-city Asthma study : Design, methods, and lessons learned. In: Journal of Asthma. 2011 ; Vol. 48, No. 10. pp. 1007-1014.
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