The search for new cardiovascular biomarkers

Robert E. Gerszten; Thomas J. Wang

doi:10.1038/nature06802

The search for new cardiovascular biomarkers

Robert E. Gerszten, Thomas J. Wang

Research output: Contribution to journal › Short survey › peer-review

298 Scopus citations

Abstract

Despite considerable advances in the treatment of cardiovascular disease, it remains the leading cause of death in developed countries. Assessment of classic cardiovascular risk factors - including high blood pressure, diabetes and smoking - has a central role in disease prevention. However, many individuals with coronary heart disease (a narrowing of the blood vessels that supply the heart) have only one, or none, of the classic risk factors. Thus, new biomarkers are needed to augment the information obtained from traditional indicators and to illuminate disease mechanisms.

Original language	English (US)
Pages (from-to)	949-952
Number of pages	4
Journal	Nature
Volume	451
Issue number	7181
DOIs	https://doi.org/10.1038/nature06802
State	Published - Feb 21 2008
Externally published	Yes

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title = "The search for new cardiovascular biomarkers",

abstract = "Despite considerable advances in the treatment of cardiovascular disease, it remains the leading cause of death in developed countries. Assessment of classic cardiovascular risk factors - including high blood pressure, diabetes and smoking - has a central role in disease prevention. However, many individuals with coronary heart disease (a narrowing of the blood vessels that supply the heart) have only one, or none, of the classic risk factors. Thus, new biomarkers are needed to augment the information obtained from traditional indicators and to illuminate disease mechanisms.",

author = "Gerszten, {Robert E.} and Wang, {Thomas J.}",

note = "Funding Information: Acknowledgements The authors are grateful for support from the National Institutes of Health (to R.E.G. and T.J.W.), the Donald W. Reynolds Foundation (to R.E.G.), the Fondation Leducq (to R.E.G.) and the American Heart Association (to T.J.W.).",

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AU - Wang, Thomas J.

N1 - Funding Information: Acknowledgements The authors are grateful for support from the National Institutes of Health (to R.E.G. and T.J.W.), the Donald W. Reynolds Foundation (to R.E.G.), the Fondation Leducq (to R.E.G.) and the American Heart Association (to T.J.W.).

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N2 - Despite considerable advances in the treatment of cardiovascular disease, it remains the leading cause of death in developed countries. Assessment of classic cardiovascular risk factors - including high blood pressure, diabetes and smoking - has a central role in disease prevention. However, many individuals with coronary heart disease (a narrowing of the blood vessels that supply the heart) have only one, or none, of the classic risk factors. Thus, new biomarkers are needed to augment the information obtained from traditional indicators and to illuminate disease mechanisms.

AB - Despite considerable advances in the treatment of cardiovascular disease, it remains the leading cause of death in developed countries. Assessment of classic cardiovascular risk factors - including high blood pressure, diabetes and smoking - has a central role in disease prevention. However, many individuals with coronary heart disease (a narrowing of the blood vessels that supply the heart) have only one, or none, of the classic risk factors. Thus, new biomarkers are needed to augment the information obtained from traditional indicators and to illuminate disease mechanisms.

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The search for new cardiovascular biomarkers

Abstract

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