The second STEP

the feasibility of repeat serial transverse enteroplasty

Hannah Piper, Biren P. Modi, Heung Bae Kim, Dario Fauza, John Glickman, Tom Jaksic

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Background: Serial transverse enteroplasty (STEP) lengthens and tapers dilated bowel. Redilation of the STEP segment occurs in some patients with intestinal failure. The feasibility of a repeat STEP procedure in a pig model is evaluated. Methods: Six pigs underwent reversal of an intestinal segment distal to the ligament of Treitz. At 6-week intervals after reversal, each animal had 2 STEP procedures on the bowel proximal to the reversed segment. Necropsy was performed up to 6 weeks after repeat STEP. Results: Bowel length increased by 11.3 ± 3.9 cm and bowel diameter decreased from a mean of 5.3 ± 0.8 to 1.8 ± 0.4 cm (P < .0001) after the first STEP. After repeat STEP, bowel length increased by 16.7 ± 13.3 cm (P < .01), and the bowel was tapered from a mean of 5.4 ± 0.9 to 2.2 ± 0.4 cm (P < .01). Five pigs did well after repeat STEP, and 1 pig had early necropsy for bowel obstruction. None had histologic evidence of bowel ischemia in the repeat STEP segment. Conclusions: A second STEP operation is feasible in a pig model and may be considered to optimize bowel length and function in select patients with intestinal failure.

Original languageEnglish (US)
Pages (from-to)1951-1956
Number of pages6
JournalJournal of Pediatric Surgery
Volume41
Issue number12
DOIs
StatePublished - Dec 1 2006

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Swine
Ligaments
Ischemia

Keywords

  • Bowel dilation
  • Bowel lengthening
  • Intestinal failure
  • Serial transverse enteroplasty
  • STEP

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

The second STEP : the feasibility of repeat serial transverse enteroplasty. / Piper, Hannah; Modi, Biren P.; Kim, Heung Bae; Fauza, Dario; Glickman, John; Jaksic, Tom.

In: Journal of Pediatric Surgery, Vol. 41, No. 12, 01.12.2006, p. 1951-1956.

Research output: Contribution to journalArticle

Piper, Hannah ; Modi, Biren P. ; Kim, Heung Bae ; Fauza, Dario ; Glickman, John ; Jaksic, Tom. / The second STEP : the feasibility of repeat serial transverse enteroplasty. In: Journal of Pediatric Surgery. 2006 ; Vol. 41, No. 12. pp. 1951-1956.
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