The septin family of GTPases: Architecture and dynamics

Research output: Contribution to journalReview article

217 Citations (Scopus)

Abstract

Septins comprise a conserved family of proteins that are found primarily in fungi and animals. These GTP-binding proteins have several roles during cell division, cytoskeletal organization and membrane-remodelling events. One factor that is crucial for their functions is the ordered assembly of individual septins into oligomeric core complexes that, in turn, form higher-order structures such as filaments, rings and gauzes. The molecular details of these interactions and the mechanism by which septin-complex assembly is regulated have remained elusive. Recently, the first detailed structural views of the septin core have emerged, and these, along with studies of septin dynamics in vivo, have provided new insight into septin-complex assembly and septin function in vivo.

Original languageEnglish (US)
Pages (from-to)478-489
Number of pages12
JournalNature Reviews Molecular Cell Biology
Volume9
Issue number6
DOIs
StatePublished - Jun 10 2008

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Septins
GTP Phosphohydrolases
GTP-Binding Proteins
Cell Division
Fungi
Membranes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Cite this

The septin family of GTPases : Architecture and dynamics. / Weirich, Christine S.; Erzberger, Jan P.; Barral, Yves.

In: Nature Reviews Molecular Cell Biology, Vol. 9, No. 6, 10.06.2008, p. 478-489.

Research output: Contribution to journalReview article

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