TY - JOUR
T1 - The Sherrington–Cushing connection
T2 - A bench to bedside collaboration at the dawn of the twentieth century
AU - Louis, Elan D.
N1 - Funding Information:
I would like to thank Melissa J. Grafe, of Yale University Library, for guidance and assistance in identifying primary source materials. There were no funding sources.
Publisher Copyright:
© 2019, © 2019 Taylor & Francis.
PY - 2020/4/2
Y1 - 2020/4/2
N2 - British physiologist Charles Sherrington (1857–1952) and American neurosurgeon Harvey Cushing (1869–1939) were seminal figures in the history of neuroscience. The two came from different worlds, one laboratory-based and the other largely clinical. Their scientific intersection, beginning in July 1901, provides a glimpse into a nascent form of “bench to bedside” collaboration, which carried with it the potential to extend the arm of neurophysiological experimentation from Sherrington’s laboratory to Cushing’s operatory. I reviewed extensive primary source materials archived at Yale University School of Medicine Library. Sherrington viewed Cushing’s bedside work as an opportunity, in humans, to extend his bench-side physiological observations on higher primates, at times almost directing Cushing in the clinic. Cushing would indeed take Sherrington’s observations on apes and extend them to his patients, and the work would eventually overturn the prevailing notion that the motor and sensory cortex were intermixed across the Rolandic fissure.
AB - British physiologist Charles Sherrington (1857–1952) and American neurosurgeon Harvey Cushing (1869–1939) were seminal figures in the history of neuroscience. The two came from different worlds, one laboratory-based and the other largely clinical. Their scientific intersection, beginning in July 1901, provides a glimpse into a nascent form of “bench to bedside” collaboration, which carried with it the potential to extend the arm of neurophysiological experimentation from Sherrington’s laboratory to Cushing’s operatory. I reviewed extensive primary source materials archived at Yale University School of Medicine Library. Sherrington viewed Cushing’s bedside work as an opportunity, in humans, to extend his bench-side physiological observations on higher primates, at times almost directing Cushing in the clinic. Cushing would indeed take Sherrington’s observations on apes and extend them to his patients, and the work would eventually overturn the prevailing notion that the motor and sensory cortex were intermixed across the Rolandic fissure.
KW - Charles Sherrington
KW - Harvey Cushing
KW - history of neurology
KW - translational research
KW - twentieth century
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U2 - 10.1080/0964704X.2019.1656377
DO - 10.1080/0964704X.2019.1656377
M3 - Article
C2 - 31503517
AN - SCOPUS:85073792981
SN - 0964-704X
VL - 29
SP - 203
EP - 220
JO - Journal of the history of the neurosciences
JF - Journal of the history of the neurosciences
IS - 2
ER -