TY - JOUR
T1 - The sigma-1 receptor
T2 - Roles in neuronal plasticity and disease
AU - Kourrich, Saïd
AU - Su, Tsung Ping
AU - Fujimoto, Michiko
AU - Bonci, Antonello
N1 - Funding Information:
This work is supported by the Intramural Research Program of NIDA, NIH/DHHS.
PY - 2012/12
Y1 - 2012/12
N2 - Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic reticulum (ER)-mitochondrion interface, referred to as the mitochondrion-associated ER membrane (MAM). Here, Sig-1Rs regulate ER-mitochondrion Ca2+ signaling. In this review, we discuss the current understanding of Sig-1R functions. Based on this, we suggest that the key cellular mechanisms linking Sig-1Rs to neurological disorders involve the translocation of Sig-1Rs from the MAM to other parts of the cell, whereby Sig-1Rs bind and modulate the activities of various ion channels, receptors, or kinases. Thus, Sig-1Rs and their associated ligands may represent new avenues for treating aspects of neurological and psychiatric diseases.
AB - Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic reticulum (ER)-mitochondrion interface, referred to as the mitochondrion-associated ER membrane (MAM). Here, Sig-1Rs regulate ER-mitochondrion Ca2+ signaling. In this review, we discuss the current understanding of Sig-1R functions. Based on this, we suggest that the key cellular mechanisms linking Sig-1Rs to neurological disorders involve the translocation of Sig-1Rs from the MAM to other parts of the cell, whereby Sig-1Rs bind and modulate the activities of various ion channels, receptors, or kinases. Thus, Sig-1Rs and their associated ligands may represent new avenues for treating aspects of neurological and psychiatric diseases.
KW - Binding immunoglobulin protein
KW - GABA receptors
KW - Glutamate receptors
KW - Mitochondrion-associated ER membrane
KW - Neuronal excitability
KW - Voltage-gated ion channels
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U2 - 10.1016/j.tins.2012.09.007
DO - 10.1016/j.tins.2012.09.007
M3 - Review article
C2 - 23102998
AN - SCOPUS:84869878432
SN - 0166-2236
VL - 35
SP - 762
EP - 771
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 12
ER -