The sign of Leser-Trelát and malignant acanthosis nigricans associated with fallopian tube carcinoma

Lindsey West; Matthew Carlson; Luke Wallis; Heather W. Goff

doi:10.1097/AOG.0000000000002920

The sign of Leser-Trelát and malignant acanthosis nigricans associated with fallopian tube carcinoma

Lindsey West, Matthew Carlson, Luke Wallis, Heather W. Goff

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

BACKGROUND: The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses. CASE: A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Her symptoms were concerning for a paraneoplastic eruption; workup revealed an elevated CA 125 level and an ovarian mass on abdominal computed tomography scan. Exploratory laparotomy revealed a stage IIIC serous fallopian tube carcinoma and a synchronous low-grade endometrioid adenocarcinoma of the endometrium. CONCLUSION: The sign of Leser-Trelát can be associated with fallopian tube carcinoma. When recognized, paraneoplastic dermatoses can prompt clinicians to initiate a workup for occult malignancy.

Original language	English (US)
Pages (from-to)	1116-1119
Number of pages	4
Journal	Obstetrics and gynecology
Volume	132
Issue number	5
DOIs	https://doi.org/10.1097/AOG.0000000000002920
State	Published - 2018

ASJC Scopus subject areas

Obstetrics and Gynecology

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10.1097/AOG.0000000000002920

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title = "The sign of Leser-Trel{\'a}t and malignant acanthosis nigricans associated with fallopian tube carcinoma",

abstract = "BACKGROUND: The sign of Leser-Trel{\'a}t is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses. CASE: A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Her symptoms were concerning for a paraneoplastic eruption; workup revealed an elevated CA 125 level and an ovarian mass on abdominal computed tomography scan. Exploratory laparotomy revealed a stage IIIC serous fallopian tube carcinoma and a synchronous low-grade endometrioid adenocarcinoma of the endometrium. CONCLUSION: The sign of Leser-Trel{\'a}t can be associated with fallopian tube carcinoma. When recognized, paraneoplastic dermatoses can prompt clinicians to initiate a workup for occult malignancy.",

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language = "English (US)",

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T1 - The sign of Leser-Trelát and malignant acanthosis nigricans associated with fallopian tube carcinoma

AU - West, Lindsey

AU - Carlson, Matthew

AU - Wallis, Luke

AU - Goff, Heather W.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses. CASE: A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Her symptoms were concerning for a paraneoplastic eruption; workup revealed an elevated CA 125 level and an ovarian mass on abdominal computed tomography scan. Exploratory laparotomy revealed a stage IIIC serous fallopian tube carcinoma and a synchronous low-grade endometrioid adenocarcinoma of the endometrium. CONCLUSION: The sign of Leser-Trelát can be associated with fallopian tube carcinoma. When recognized, paraneoplastic dermatoses can prompt clinicians to initiate a workup for occult malignancy.

AB - BACKGROUND: The sign of Leser-Trelát is controversial and rarely reported in gynecologic malignancies. It is characterized by rapid development of new or enlarging seborrheic keratoses. CASE: A 78-year-old woman presented with unintentional weight loss and new-onset erythematous patches and plaques with thickened, rugated skin and stuck-on brown waxy papules on the chest and back. Her symptoms were concerning for a paraneoplastic eruption; workup revealed an elevated CA 125 level and an ovarian mass on abdominal computed tomography scan. Exploratory laparotomy revealed a stage IIIC serous fallopian tube carcinoma and a synchronous low-grade endometrioid adenocarcinoma of the endometrium. CONCLUSION: The sign of Leser-Trelát can be associated with fallopian tube carcinoma. When recognized, paraneoplastic dermatoses can prompt clinicians to initiate a workup for occult malignancy.

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The sign of Leser-Trelát and malignant acanthosis nigricans associated with fallopian tube carcinoma

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