The significance of nasal carriage of Staphylococcus aureus and the incidence of postoperative wound infection

R. P. Wenzel, T. M. Perl

Research output: Contribution to journalReview article

207 Citations (Scopus)

Abstract

Staphylococcus aureus infections are associated with considerable morbidity and, in certain situations, mortality. The association between the nasal carriage of S. aureus and subsequent infection has been comprehensively established in a variety of clinical settings, in particular, patients undergoing haemodialysis and continuous ambulatory peritoneal dialysis (CAPD), and in patients undergoing surgery. Postoperative wound infections are associated with a high degree of morbidity and represent an important medical issue. Until recently, eradication of S. aureus nasal carriage by various topical and systemic agents had proved unsuccessful. Mupirocin is a novel topical antibiotic with excellent antibacterial activity against staphylococci. Recent studies have demonstrated that intranasal administration of mupirocin is effective in eradicating the nasal carriage of S. aureus and in reducing the incidence of S. aureus infections in haemodialysis and CAPD patients. It has been suggested that sufficient evidence now exists to test the hypothesis that eradication of the carrier state in surgical patients preoperatively may reduce the incidence of S. aureus postoperative wound infections.

Original languageEnglish (US)
Pages (from-to)13-24
Number of pages12
JournalJournal of Hospital Infection
Volume31
Issue number1
DOIs
StatePublished - Jan 1 1995

Fingerprint

Surgical Wound Infection
Nose
Staphylococcus aureus
Incidence
Mupirocin
Continuous Ambulatory Peritoneal Dialysis
Renal Dialysis
Infection
Morbidity
Carrier State
Intranasal Administration
Staphylococcus
Anti-Bacterial Agents
Mortality

Keywords

  • mupirocin
  • Staphylococcus aureus
  • surgery
  • wound infection

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

The significance of nasal carriage of Staphylococcus aureus and the incidence of postoperative wound infection. / Wenzel, R. P.; Perl, T. M.

In: Journal of Hospital Infection, Vol. 31, No. 1, 01.01.1995, p. 13-24.

Research output: Contribution to journalReview article

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