The solid variant of adenoid cystic carcinoma of the cervix

J. Albores-Saavedra, C. Manivel, A. Mora, F. Vuitch, S. Milchgrub, E. Gould

Research output: Contribution to journalArticle

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Abstract

We studied seven examples of the solid variant of adenoid cystic carcinoma of the uterine cervix in postmenopausal women who presented with vaginal bleeding and a large ulcerated or polypoid cervical mass. The tumors lacked the characteristic cribriform pattern of conventional adenoid cystic carcinoma. The neoplastic cells were small, undifferentiated, or basaloid and grew in cords, nests, trabeculae, and nodules. Foci of squamous cell carcinoma were seen in three tumors and areas of necrosis in four. A characteristic feature was the production of abundant periodic acid-Schiff's procedure (PAS)-positive basement membrane material that was immunoreactive for collagen IV and that in some areas compressed tumor cells. Electron microscopy on three cases showed globules and cylinders of redundant basal lamina. The tumor cells were joined by desmosomes and contained bundles of tonofilaments. Material similar to basement membrane material appeared to be intracytoplasmic in two tumors. No neurosecretory granules or myoepithelial cells were found. Four deaths were tumor related. Two patients are currently alive, but with local recurrence or metastases; another is alive and well 19 months after surgery. We believe that the solid variant of adenoid cystic carcinoma of the cervix is a distinctive neoplasm that should be separated from small cell carcinomas with or without endocrine features, adenoid basal cell carcinoma, and squamous cell carcinoma.

Original languageEnglish (US)
Pages (from-to)2-10
Number of pages9
JournalInternational Journal of Gynecological Pathology
Volume11
Issue number1
StatePublished - 1992

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Adenoid Cystic Carcinoma
Cervix Uteri
Neoplasms
Basement Membrane
Squamous Cell Carcinoma
Adenoids
Desmosomes
Periodic Acid
Small Cell Carcinoma
Intermediate Filaments
Uterine Hemorrhage
Basal Cell Carcinoma
Electron Microscopy
Necrosis
Collagen
Neoplasm Metastasis
Recurrence

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pathology and Forensic Medicine

Cite this

Albores-Saavedra, J., Manivel, C., Mora, A., Vuitch, F., Milchgrub, S., & Gould, E. (1992). The solid variant of adenoid cystic carcinoma of the cervix. International Journal of Gynecological Pathology, 11(1), 2-10.

The solid variant of adenoid cystic carcinoma of the cervix. / Albores-Saavedra, J.; Manivel, C.; Mora, A.; Vuitch, F.; Milchgrub, S.; Gould, E.

In: International Journal of Gynecological Pathology, Vol. 11, No. 1, 1992, p. 2-10.

Research output: Contribution to journalArticle

Albores-Saavedra, J, Manivel, C, Mora, A, Vuitch, F, Milchgrub, S & Gould, E 1992, 'The solid variant of adenoid cystic carcinoma of the cervix', International Journal of Gynecological Pathology, vol. 11, no. 1, pp. 2-10.
Albores-Saavedra, J. ; Manivel, C. ; Mora, A. ; Vuitch, F. ; Milchgrub, S. ; Gould, E. / The solid variant of adenoid cystic carcinoma of the cervix. In: International Journal of Gynecological Pathology. 1992 ; Vol. 11, No. 1. pp. 2-10.
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