TY - JOUR
T1 - The solid variant of adenoid cystic carcinoma of the cervix
AU - Albores-Saavedra, J.
AU - Manivel, C.
AU - Mora, A.
AU - Vuitch, F.
AU - Milchgrub, S.
AU - Gould, E.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1992/1
Y1 - 1992/1
N2 - We studied seven examples of the solid variant of adenoid cystic carcinoma of the uterine cervix in postmenopausal women who presented with vaginal bleeding and a large ulcerated or polypoid cervical mass. The tumors lacked the characteristic cribriform pattern of conventional adenoid cystic carcinoma. The neoplastic cells were small, undifferentiated, or basaloid and grew in cords, nests, trabeculae, and nodules. Foci of squamous cell carcinoma were seen in three tumors and areas of necrosis in four. A characteristic feature was the production of abundant periodic acid-Schiffs procedure (PAS)-positive basement membrane material that was immunoreactive for collagen IV and that in some areascompressed tumor cells. Electron microscopy on three cases showed globules and cylinders of redundant basal lamina. The tumor cells were joined by desmosomes and contained bundles of tonofilaments. Material similar to basement membrane material appeared to be intracytoplasmic in two tumors. No neurosecretory granules or myoepithelial cells were found. Four deaths were tumor related. Two patients are currently alive, but with local recurrence or metastases; another is alive and well 19 months after surgery. We believe that thesolid variant of adenoid cystic carcinoma of the cervix is a distinctive neoplasm that should be separated from small cell carcinomas with or without endocrine features, adenoidbasal cell carcinoma, and squamous cell carcinoma.
AB - We studied seven examples of the solid variant of adenoid cystic carcinoma of the uterine cervix in postmenopausal women who presented with vaginal bleeding and a large ulcerated or polypoid cervical mass. The tumors lacked the characteristic cribriform pattern of conventional adenoid cystic carcinoma. The neoplastic cells were small, undifferentiated, or basaloid and grew in cords, nests, trabeculae, and nodules. Foci of squamous cell carcinoma were seen in three tumors and areas of necrosis in four. A characteristic feature was the production of abundant periodic acid-Schiffs procedure (PAS)-positive basement membrane material that was immunoreactive for collagen IV and that in some areascompressed tumor cells. Electron microscopy on three cases showed globules and cylinders of redundant basal lamina. The tumor cells were joined by desmosomes and contained bundles of tonofilaments. Material similar to basement membrane material appeared to be intracytoplasmic in two tumors. No neurosecretory granules or myoepithelial cells were found. Four deaths were tumor related. Two patients are currently alive, but with local recurrence or metastases; another is alive and well 19 months after surgery. We believe that thesolid variant of adenoid cystic carcinoma of the cervix is a distinctive neoplasm that should be separated from small cell carcinomas with or without endocrine features, adenoidbasal cell carcinoma, and squamous cell carcinoma.
KW - Adenoid cystic carcinoma
KW - Basement membrane
KW - Electron microscopy
KW - Immunohistochemistry
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U2 - 10.1097/00004347-199201000-00002
DO - 10.1097/00004347-199201000-00002
M3 - Article
C2 - 1373414
AN - SCOPUS:0026569386
SN - 0277-1691
VL - 11
SP - 2
EP - 10
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
IS - 1
ER -