TY - JOUR
T1 - The Somogyi Phenomenon
T2 - Sacred Cow or Bull?
AU - Raskin, Philip
PY - 1984/4
Y1 - 1984/4
N2 - Posthypoglycemic hyperglycemia (Somogyi phenomenon) occurs infrequently in insulin-treated diabetic patients. When it occurs it is often in children and adolescents, or patients with a short duration of diabetes. Marked hyperglycemia (>220 mg/dL) after hypoglycemia results from a large meal to relieve the symptoms of hypoglycemia. Posthypoglycemic hyperglycemia correlates with falling plasma insulin levels, rather than increasing concentrations of counterregulatory hormones, whose secretion may be defective. Asymptomatic nocturnal hypoglycemia is common but subsequent fasting hyperglycemia is not necessarily the result of “rebound.” More likely, fasting hyperglycemia is due to a falling predawn insulin level. Nocturnal hypoglycemia is dealt with by a readjustment in the timing and dose of insulin. The failure of the Somogyi phenomenon to occur puts insulindependent diabetic patients at increased risk to potential lethal consequences of nocturnal hypoglycemia.
AB - Posthypoglycemic hyperglycemia (Somogyi phenomenon) occurs infrequently in insulin-treated diabetic patients. When it occurs it is often in children and adolescents, or patients with a short duration of diabetes. Marked hyperglycemia (>220 mg/dL) after hypoglycemia results from a large meal to relieve the symptoms of hypoglycemia. Posthypoglycemic hyperglycemia correlates with falling plasma insulin levels, rather than increasing concentrations of counterregulatory hormones, whose secretion may be defective. Asymptomatic nocturnal hypoglycemia is common but subsequent fasting hyperglycemia is not necessarily the result of “rebound.” More likely, fasting hyperglycemia is due to a falling predawn insulin level. Nocturnal hypoglycemia is dealt with by a readjustment in the timing and dose of insulin. The failure of the Somogyi phenomenon to occur puts insulindependent diabetic patients at increased risk to potential lethal consequences of nocturnal hypoglycemia.
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U2 - 10.1001/archinte.1984.00350160137022
DO - 10.1001/archinte.1984.00350160137022
M3 - Article
C2 - 6370162
AN - SCOPUS:0021364176
SN - 0003-9926
VL - 144
SP - 781
EP - 787
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 4
ER -