Abstract
Background: Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations. Objective: To characterize the diversity of cutaneous manifestations of COVID-19 and facilitate understanding of the underlying pathophysiology. Methods: Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies. Results: The registry collected 716 cases of new-onset dermatologic symptoms in patients with confirmed/suspected COVID-19. Of the 171 patients in the registry with laboratory-confirmed COVID-19, the most common morphologies were morbilliform (22%), pernio-like (18%), urticarial (16%), macular erythema (13%), vesicular (11%), papulosquamous (9.9%), and retiform purpura (6.4%). Pernio-like lesions were common in patients with mild disease, whereas retiform purpura presented exclusively in ill, hospitalized patients. Limitations: We cannot estimate incidence or prevalence. Confirmation bias is possible. Conclusions: This study highlights the array of cutaneous manifestations associated with COVID-19. Many morphologies were nonspecific, whereas others may provide insight into potential immune or inflammatory pathways in COVID-19 pathophysiology.
Original language | English (US) |
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Pages (from-to) | 1118-1129 |
Number of pages | 12 |
Journal | Journal of the American Academy of Dermatology |
Volume | 83 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2020 |
Keywords
- COVID toes
- COVID-19
- SARS-CoV-2
- dermatology
- global health
- macular erythema
- morbilliform
- pernio
- public health
- registry
- retiform purpura
- urticarial
- vesicular
ASJC Scopus subject areas
- Dermatology