The spindle checkpoint and chromosomal stability.

W. Qi, H. Yu

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Normal human somatic cells contain 46 chromosomes (22 pairs of autosomes and two sex chromosomes). Chromosome missegregation leads to abnormal numbers of chromosomes or aneuploidy. This form of genetic instability alters the dosages of large subsets of genes, which can result in severe disease phenotypes. Most human cancer cells are aneuploid. It is generally believed that aneuploidy contributes to cancer formation. The spindle checkpoint is a cell-cycle surveillance mechanism that ensures the fidelity of chromosome segregation during mitosis and meiosis. In this article, we review our current understanding of the molecular basis of the spindle checkpoint and the recent evidence that links the malfunction of this checkpoint to aneuploidy and tumorigenesis.

Original languageEnglish (US)
Pages (from-to)116-130
Number of pages15
JournalGenome Dynamics
Volume1
StatePublished - 2006

Fingerprint

Chromosomal Instability
aneuploidy
Aneuploidy
chromosome
chromosomes
Chromosomes
cancer
Chromosomes, Human, Pair 22
Chromosome Segregation
Sex Chromosomes
chromosome segregation
autosomes
Meiosis
sex chromosomes
somatic cells
Mitosis
meiosis
carcinogenesis
mitosis
cell cycle

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Cite this

The spindle checkpoint and chromosomal stability. / Qi, W.; Yu, H.

In: Genome Dynamics, Vol. 1, 2006, p. 116-130.

Research output: Contribution to journalArticle

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