The STAR*D study: Treating depression in the real world

Bradley N. Gaynes, A. John Rush, Madhukar H. Trivedi, Stephen R. Wisniewski, Donald Spencer, Maurizio Fava

Research output: Contribution to journalArticle

87 Scopus citations


The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut "winner," it does provide guidance on how to start therapy and how to proceed if initial treatment fails.

Original languageEnglish (US)
Pages (from-to)57-66
Number of pages10
JournalCleveland Clinic Journal of Medicine
Issue number1
Publication statusPublished - Jan 2008


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gaynes, B. N., Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Spencer, D., & Fava, M. (2008). The STAR*D study: Treating depression in the real world. Cleveland Clinic Journal of Medicine, 75(1), 57-66.