The STAR*D study: Treating depression in the real world

Bradley N. Gaynes, A. John Rush, Madhukar H. Trivedi, Stephen R. Wisniewski, Donald Spencer, Maurizio Fava

Research output: Contribution to journalArticlepeer-review

148 Scopus citations


The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study evaluated feasible treatment strategies to improve clinical outcomes for real-world patients with treatment-resistant depression. Although the study found no clear-cut "winner," it does provide guidance on how to start therapy and how to proceed if initial treatment fails.

Original languageEnglish (US)
Pages (from-to)57-66
Number of pages10
JournalCleveland Clinic journal of medicine
Issue number1
StatePublished - Jan 2008

ASJC Scopus subject areas

  • Medicine(all)


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