TY - JOUR
T1 - The stem cell niche
T2 - Theme and variations
AU - Ohlstein, Benjamin
AU - Kai, Toshie
AU - Decotto, Eva
AU - Spradling, Allan
PY - 2004/12
Y1 - 2004/12
N2 - Stem cells in animal tissues are often located and controlled by special tissue microenvironments known as niches. Studies of stem cell niches in model systems such as Drosophila have revealed adhesive interactions, cell cycle modifications and intercellular signals that operate to control stem cell behavior. Candidate niches and regulatory molecules have also been identified in many mammalian tissues, including bone marrow, skin, gut and brain. While niches are an ancient evolutionary device with conserved features across diverse organisms, we suggest that certain niches display important differences in their organization and function.
AB - Stem cells in animal tissues are often located and controlled by special tissue microenvironments known as niches. Studies of stem cell niches in model systems such as Drosophila have revealed adhesive interactions, cell cycle modifications and intercellular signals that operate to control stem cell behavior. Candidate niches and regulatory molecules have also been identified in many mammalian tissues, including bone marrow, skin, gut and brain. While niches are an ancient evolutionary device with conserved features across diverse organisms, we suggest that certain niches display important differences in their organization and function.
UR - http://www.scopus.com/inward/record.url?scp=7744227209&partnerID=8YFLogxK
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U2 - 10.1016/j.ceb.2004.09.003
DO - 10.1016/j.ceb.2004.09.003
M3 - Review article
C2 - 15530783
AN - SCOPUS:7744227209
SN - 0955-0674
VL - 16
SP - 693
EP - 699
JO - Current Opinion in Cell Biology
JF - Current Opinion in Cell Biology
IS - 6
ER -