Abstract
G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.
Original language | English (US) |
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Pages (from-to) | 356-363 |
Number of pages | 8 |
Journal | Nature |
Volume | 459 |
Issue number | 7245 |
DOIs | |
State | Published - May 21 2009 |
ASJC Scopus subject areas
- General