The structure and function of G-protein-coupled receptors

Daniel M. Rosenbaum, Søren G F Rasmussen, Brian K. Kobilka

Research output: Contribution to journalArticle

1149 Citations (Scopus)

Abstract

G-protein-coupled receptors (GPCRs) mediate most of our physiological responses to hormones, neurotransmitters and environmental stimulants, and so have great potential as therapeutic targets for a broad spectrum of diseases. They are also fascinating molecules from the perspective of membrane-protein structure and biology. Great progress has been made over the past three decades in understanding diverse GPCRs, from pharmacology to functional characterization in vivo. Recent high-resolution structural studies have provided insights into the molecular mechanisms of GPCR activation and constitutive activity.

Original languageEnglish (US)
Pages (from-to)356-363
Number of pages8
JournalNature
Volume459
Issue number7245
DOIs
StatePublished - May 21 2009

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G-Protein-Coupled Receptors
Neurotransmitter Agents
Membrane Proteins
Hormones
Pharmacology
Therapeutics

ASJC Scopus subject areas

  • General

Cite this

The structure and function of G-protein-coupled receptors. / Rosenbaum, Daniel M.; Rasmussen, Søren G F; Kobilka, Brian K.

In: Nature, Vol. 459, No. 7245, 21.05.2009, p. 356-363.

Research output: Contribution to journalArticle

Rosenbaum, DM, Rasmussen, SGF & Kobilka, BK 2009, 'The structure and function of G-protein-coupled receptors', Nature, vol. 459, no. 7245, pp. 356-363. https://doi.org/10.1038/nature08144
Rosenbaum, Daniel M. ; Rasmussen, Søren G F ; Kobilka, Brian K. / The structure and function of G-protein-coupled receptors. In: Nature. 2009 ; Vol. 459, No. 7245. pp. 356-363.
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