Abstract
GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The α subunit contains a DNA-binding domain that is a member of the ETS family, whereas the α subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPα/β ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2.15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein- protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPα ETS domain binds to its core GGA DNA-recognition motif.
Original language | English (US) |
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Pages (from-to) | 1037-1041 |
Number of pages | 5 |
Journal | Science |
Volume | 279 |
Issue number | 5353 |
DOIs | |
State | Published - Feb 13 1998 |
ASJC Scopus subject areas
- General