TY - JOUR
T1 - The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by penicillium sp
AU - Kumagai, H.
AU - Nishida, H.
AU - Imamura, N.
AU - Tomoda, H.
AU - Omura, S.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1990
Y1 - 1990
N2 - The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp., have been deduced to be I, II and III, respectively, on the basis of spectroscopic and 1H and 13C NMR spectral data. The molecular structure of atpenin A4 with absolute configurations was finally confirmed to be 2′S,4′S′,5′S-5,6-dimethoxy-4-hydroxy-5′-chloro-2′,4′-dimethyl-1′-oxoheptyl-2-hydroxypyridine (I′) by the single crystal X-ray crystallographic analysis. The absolute configurations of atpenins A5 and B were also expected to be 2′S,4′S,5′R-II(II′) and 2′S,4′R-III(III′), respectively.
AB - The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp., have been deduced to be I, II and III, respectively, on the basis of spectroscopic and 1H and 13C NMR spectral data. The molecular structure of atpenin A4 with absolute configurations was finally confirmed to be 2′S,4′S′,5′S-5,6-dimethoxy-4-hydroxy-5′-chloro-2′,4′-dimethyl-1′-oxoheptyl-2-hydroxypyridine (I′) by the single crystal X-ray crystallographic analysis. The absolute configurations of atpenins A5 and B were also expected to be 2′S,4′S,5′R-II(II′) and 2′S,4′R-III(III′), respectively.
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U2 - 10.7164/antibiotics.43.1553
DO - 10.7164/antibiotics.43.1553
M3 - Article
C2 - 2276974
AN - SCOPUS:0025686870
SN - 0021-8820
VL - 43
SP - 1553
EP - 1558
JO - The Journal of Antibiotics
JF - The Journal of Antibiotics
IS - 12
ER -