The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp.

H. Kumagai, H. Nishida, N. Imamura, H. Tomoda, S. Omura

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp., have been deduced to be I, II and III, respectively, on the basis of spectroscopic and 1H and 13C NMR spectral data. The molecular structure of atpenin A4 with absolute configurations was finally confirmed to be 2'S,4'S,5'S-5,6-dimethoxy-4-hydroxy-5'-chloro-2',4'-dimethyl-1'- oxoheptyl-2-hydroxypyridine (I') by the single crystal X-ray crystallographic analysis. The absolute configurations of atpenins A5 and B were also expected to be 2'S,4'S,5'R-II(II') and 2'S,4'R-III(III'), respectively.

Original languageEnglish (US)
Pages (from-to)1553-1558
Number of pages6
JournalJournal of Antibiotics
Volume43
Issue number12
StatePublished - 1990

Fingerprint

Antifungal Agents
Penicillium
Molecular Structure
X-Rays
2-hydroxypyridine
Proton Magnetic Resonance Spectroscopy
Carbon-13 Magnetic Resonance Spectroscopy
atpenin A4

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Kumagai, H., Nishida, H., Imamura, N., Tomoda, H., & Omura, S. (1990). The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp. Journal of Antibiotics, 43(12), 1553-1558.

The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp. / Kumagai, H.; Nishida, H.; Imamura, N.; Tomoda, H.; Omura, S.

In: Journal of Antibiotics, Vol. 43, No. 12, 1990, p. 1553-1558.

Research output: Contribution to journalArticle

Kumagai, H, Nishida, H, Imamura, N, Tomoda, H & Omura, S 1990, 'The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp.', Journal of Antibiotics, vol. 43, no. 12, pp. 1553-1558.
Kumagai, H. ; Nishida, H. ; Imamura, N. ; Tomoda, H. ; Omura, S. / The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp. In: Journal of Antibiotics. 1990 ; Vol. 43, No. 12. pp. 1553-1558.
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