The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by penicillium sp

H. Kumagai, H. Nishida, N. Imamura, H. Tomoda, S. Omura

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp., have been deduced to be I, II and III, respectively, on the basis of spectroscopic and 1H and 13C NMR spectral data. The molecular structure of atpenin A4 with absolute configurations was finally confirmed to be 2′S,4′S′,5′S-5,6-dimethoxy-4-hydroxy-5′-chloro-2′,4′-dimethyl-1′-oxoheptyl-2-hydroxypyridine (I′) by the single crystal X-ray crystallographic analysis. The absolute configurations of atpenins A5 and B were also expected to be 2′S,4′S,5′R-II(II′) and 2′S,4′R-III(III′), respectively.

Original languageEnglish (US)
Pages (from-to)1553-1558
Number of pages6
JournalThe Journal of Antibiotics
Volume43
Issue number12
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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