TY - JOUR
T1 - The syk/zap-70 protein tyrosine kinase connection to antigen receptor signalling processes
AU - Van Oers, Niodai S C
AU - Weiss, Arthur
N1 - Funding Information:
This work was supported in part by a grant from the Human Frontier Science Program to N. van Oers (LT-505/93) and by a National Institutes of Health grant (GM39553) to A. Weiss.
PY - 1995
Y1 - 1995
N2 - The T- and B-cell receptor (TCR and BCR) signal tranduction processes involve a coordinated interplay between two classes of non-receptor protein tyrosine kinases (PTKs), the Src-farrily and the Syk/ZAP-70 family of PTKs. Following antigen-receptor stimulation, the Src-family of PTKs mediate the phosphorylation of tyrocine residues contained in a signalling motif localized in the TCR and BCR subunits. The phosphorylation of this signalling motif recruits the Syk/ZAP-70 family of PTKs into the antigen receptor complex. This mechanism requires the tandem SH2 domains in ZAP-70 complexing to two critically spaced phosphotyrosine residues within the signalling motif. The clustering of Syk/ZAP-70 and cross-talk between this family and the Src-PTKs regulates subsequent signalling events that lead to a variety of cellular responses, such as antibody secretion, lymphokine production, cytolytic activity, proliferation, differentiation and cell survival.
AB - The T- and B-cell receptor (TCR and BCR) signal tranduction processes involve a coordinated interplay between two classes of non-receptor protein tyrosine kinases (PTKs), the Src-farrily and the Syk/ZAP-70 family of PTKs. Following antigen-receptor stimulation, the Src-family of PTKs mediate the phosphorylation of tyrocine residues contained in a signalling motif localized in the TCR and BCR subunits. The phosphorylation of this signalling motif recruits the Syk/ZAP-70 family of PTKs into the antigen receptor complex. This mechanism requires the tandem SH2 domains in ZAP-70 complexing to two critically spaced phosphotyrosine residues within the signalling motif. The clustering of Syk/ZAP-70 and cross-talk between this family and the Src-PTKs regulates subsequent signalling events that lead to a variety of cellular responses, such as antibody secretion, lymphokine production, cytolytic activity, proliferation, differentiation and cell survival.
KW - BCR
KW - Intracellular signalling
KW - Protein tyrosine kinases
KW - Syk
KW - TCR
KW - ZAP-70
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U2 - 10.1006/smim.1995.0027
DO - 10.1006/smim.1995.0027
M3 - Article
C2 - 8520027
AN - SCOPUS:0029347999
SN - 1044-5323
VL - 7
SP - 227
EP - 236
JO - Seminars in Immunology
JF - Seminars in Immunology
IS - 4
ER -