The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes

Niodai S C Van Oers, Arthur Weiss

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

The T- and B-cell receptor (TCR and BCR) signal tranduction processes involve a coordinated interplay between two classes of non-receptor protein tyrosine kinases (PTKs), the Src-farrily and the Syk/ZAP-70 family of PTKs. Following antigen-receptor stimulation, the Src-family of PTKs mediate the phosphorylation of tyrocine residues contained in a signalling motif localized in the TCR and BCR subunits. The phosphorylation of this signalling motif recruits the Syk/ZAP-70 family of PTKs into the antigen receptor complex. This mechanism requires the tandem SH2 domains in ZAP-70 complexing to two critically spaced phosphotyrosine residues within the signalling motif. The clustering of Syk/ZAP-70 and cross-talk between this family and the Src-PTKs regulates subsequent signalling events that lead to a variety of cellular responses, such as antibody secretion, lymphokine production, cytolytic activity, proliferation, differentiation and cell survival.

Original languageEnglish (US)
Pages (from-to)227-236
Number of pages10
JournalSeminars in Immunology
Volume7
Issue number4
Publication statusPublished - 1995

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Keywords

  • BCR
  • Intracellular signalling
  • Protein tyrosine kinases
  • Syk
  • TCR
  • ZAP-70

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Infectious Diseases

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