The Syndromes of Androgen Resistance

The concept that endocrine disease can result from resistance to hormone action was elaborated in 1942 by Albright et al., who deduced that pseudohypoparathyroidism resulted from peripheral resistance to the action of parathyroid hormone.¹ In 1957 Wilkins reported that the administration of methyltestosterone to a male pseudohermaphrodite with the syndrome of testicular feminization failed to result in virilization,² and a large body of information has since indicated that this disorder is due to resistance to the action of androgen during both embryogenesis and postnatal life.³ Additional syndromes of androgen resistance that have also been delineated range from other types of.