Abstract
Metal complexes of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid) - peptide conjugates are increasingly used as targeted imaging and therapeutic radiopharmaceuticals and MRI contrast agents. This review covers the bifunctional derivatives of DOTA, the solution and solid-phase synthesis of DOTA - peptide conjugates, their coordination and chelation chemistry, and the biomedical applications of various DOTA - peptide conjugate metal complexes.
Original language | English (US) |
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Pages (from-to) | 391-402 |
Number of pages | 12 |
Journal | Bioconjugate Chemistry |
Volume | 19 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2008 |
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Biomedical Engineering
- Pharmacology
- Pharmaceutical Science
- Organic Chemistry