The synthesis of new, selected analogues of the pro-apoptotic and anticancer molecule HA 14-1

Danielle Grée, Samuel Vorin, Vijay L. Manthati, Frédéric Caijo, Guillaume Viault, Florence Manero, Philippe Juin, René Grée

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

A new and versatile strategy has been developed towards HA 14-1 analogues, selectively modified on position 4 and/or on the primary amine function. An important aspect was the appropriate selection of the phenol protective group in the 5-bromosalicylaldehyde, allowing the isolation of the key intermediate the 2H-benzopyrane-2-imine 2′.

Original languageEnglish (US)
Pages (from-to)3276-3278
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number20
DOIs
StatePublished - May 12 2008

Keywords

  • Anticancer
  • Bcl-2
  • Benzopyrane
  • HA 14-1

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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