Abstract
We report the nonrandom occurrence, frequency, and degree of immunophenotype association of the t(1;14)(p34; q11) in children with acute lymphoblastic leukemia (ALL). This chromosomal abnormality occurred in leukemia cells from 5 of 1,630 (0.3%) consecutive children with newly diagnosed ALL who were entered on a single Pediatric Oncology Group classification study (POG 8600) between January 1986 and February 1989. The frequency of the t(1;14) was 3% (5 of 168 cases) in children with T-cell ALL. All five cases had pseudodiploid karyotypes, and in 3 cases the t(1;14) was accompanied by a deletion of the long arm of chromosome 6. This translocation is of special interest because the breakpoint on chromosome 14 in band q11 corresponds to the assigned locus of the T-cell receptor α/δ chain gene. All five of our patients and three cases reported previously have had T-cell ALL. These findings, considered together, suggest that this translocation is specific for T-cell ALL and that a gene in the 1p34 region may play an important role in malignant transformation of thymocytes.
Original language | English (US) |
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Pages (from-to) | 1220-1224 |
Number of pages | 5 |
Journal | Blood |
Volume | 76 |
Issue number | 6 |
State | Published - Sep 15 1990 |
ASJC Scopus subject areas
- Biochemistry
- Immunology
- Hematology
- Cell Biology