The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia

A Pediatric Oncology Group study

Andrew J. Carroll, William M. Crist, Michael P. Link, Michael D. Amylon, D. Jeanette Pullen, Abdel H. Ragab, George R. Buchanan, Robert S. Wimmer, Teresa J. Vietti

Research output: Contribution to journalArticle

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Abstract

We report the nonrandom occurrence, frequency, and degree of immunophenotype association of the t(1;14)(p34; q11) in children with acute lymphoblastic leukemia (ALL). This chromosomal abnormality occurred in leukemia cells from 5 of 1,630 (0.3%) consecutive children with newly diagnosed ALL who were entered on a single Pediatric Oncology Group classification study (POG 8600) between January 1986 and February 1989. The frequency of the t(1;14) was 3% (5 of 168 cases) in children with T-cell ALL. All five cases had pseudodiploid karyotypes, and in 3 cases the t(1;14) was accompanied by a deletion of the long arm of chromosome 6. This translocation is of special interest because the breakpoint on chromosome 14 in band q11 corresponds to the assigned locus of the T-cell receptor α/δ chain gene. All five of our patients and three cases reported previously have had T-cell ALL. These findings, considered together, suggest that this translocation is specific for T-cell ALL and that a gene in the 1p34 region may play an important role in malignant transformation of thymocytes.

Original languageEnglish (US)
Pages (from-to)1220-1224
Number of pages5
JournalBlood
Volume76
Issue number6
StatePublished - Sep 15 1990

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Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics
Oncology
T-cells
Chromosomes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Genes
T-Cell Receptor Genes
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 6
Thymocytes
T-Cell Antigen Receptor
Karyotype
Chromosome Aberrations
Leukemia

ASJC Scopus subject areas

  • Hematology

Cite this

Carroll, A. J., Crist, W. M., Link, M. P., Amylon, M. D., Pullen, D. J., Ragab, A. H., ... Vietti, T. J. (1990). The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: A Pediatric Oncology Group study. Blood, 76(6), 1220-1224.

The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia : A Pediatric Oncology Group study. / Carroll, Andrew J.; Crist, William M.; Link, Michael P.; Amylon, Michael D.; Pullen, D. Jeanette; Ragab, Abdel H.; Buchanan, George R.; Wimmer, Robert S.; Vietti, Teresa J.

In: Blood, Vol. 76, No. 6, 15.09.1990, p. 1220-1224.

Research output: Contribution to journalArticle

Carroll, AJ, Crist, WM, Link, MP, Amylon, MD, Pullen, DJ, Ragab, AH, Buchanan, GR, Wimmer, RS & Vietti, TJ 1990, 'The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: A Pediatric Oncology Group study', Blood, vol. 76, no. 6, pp. 1220-1224.
Carroll AJ, Crist WM, Link MP, Amylon MD, Pullen DJ, Ragab AH et al. The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia: A Pediatric Oncology Group study. Blood. 1990 Sep 15;76(6):1220-1224.
Carroll, Andrew J. ; Crist, William M. ; Link, Michael P. ; Amylon, Michael D. ; Pullen, D. Jeanette ; Ragab, Abdel H. ; Buchanan, George R. ; Wimmer, Robert S. ; Vietti, Teresa J. / The t(1;14)(p34;q11) is nonrandom and restricted to T-cell acute lymphoblastic leukemia : A Pediatric Oncology Group study. In: Blood. 1990 ; Vol. 76, No. 6. pp. 1220-1224.
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abstract = "We report the nonrandom occurrence, frequency, and degree of immunophenotype association of the t(1;14)(p34; q11) in children with acute lymphoblastic leukemia (ALL). This chromosomal abnormality occurred in leukemia cells from 5 of 1,630 (0.3{\%}) consecutive children with newly diagnosed ALL who were entered on a single Pediatric Oncology Group classification study (POG 8600) between January 1986 and February 1989. The frequency of the t(1;14) was 3{\%} (5 of 168 cases) in children with T-cell ALL. All five cases had pseudodiploid karyotypes, and in 3 cases the t(1;14) was accompanied by a deletion of the long arm of chromosome 6. This translocation is of special interest because the breakpoint on chromosome 14 in band q11 corresponds to the assigned locus of the T-cell receptor α/δ chain gene. All five of our patients and three cases reported previously have had T-cell ALL. These findings, considered together, suggest that this translocation is specific for T-cell ALL and that a gene in the 1p34 region may play an important role in malignant transformation of thymocytes.",
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N2 - We report the nonrandom occurrence, frequency, and degree of immunophenotype association of the t(1;14)(p34; q11) in children with acute lymphoblastic leukemia (ALL). This chromosomal abnormality occurred in leukemia cells from 5 of 1,630 (0.3%) consecutive children with newly diagnosed ALL who were entered on a single Pediatric Oncology Group classification study (POG 8600) between January 1986 and February 1989. The frequency of the t(1;14) was 3% (5 of 168 cases) in children with T-cell ALL. All five cases had pseudodiploid karyotypes, and in 3 cases the t(1;14) was accompanied by a deletion of the long arm of chromosome 6. This translocation is of special interest because the breakpoint on chromosome 14 in band q11 corresponds to the assigned locus of the T-cell receptor α/δ chain gene. All five of our patients and three cases reported previously have had T-cell ALL. These findings, considered together, suggest that this translocation is specific for T-cell ALL and that a gene in the 1p34 region may play an important role in malignant transformation of thymocytes.

AB - We report the nonrandom occurrence, frequency, and degree of immunophenotype association of the t(1;14)(p34; q11) in children with acute lymphoblastic leukemia (ALL). This chromosomal abnormality occurred in leukemia cells from 5 of 1,630 (0.3%) consecutive children with newly diagnosed ALL who were entered on a single Pediatric Oncology Group classification study (POG 8600) between January 1986 and February 1989. The frequency of the t(1;14) was 3% (5 of 168 cases) in children with T-cell ALL. All five cases had pseudodiploid karyotypes, and in 3 cases the t(1;14) was accompanied by a deletion of the long arm of chromosome 6. This translocation is of special interest because the breakpoint on chromosome 14 in band q11 corresponds to the assigned locus of the T-cell receptor α/δ chain gene. All five of our patients and three cases reported previously have had T-cell ALL. These findings, considered together, suggest that this translocation is specific for T-cell ALL and that a gene in the 1p34 region may play an important role in malignant transformation of thymocytes.

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