The targeting and assembly of peroxisomal proteins: Some old rules do not apply

James A. McNew, Joel M. Goodman

Research output: Contribution to journalReview article

145 Citations (Scopus)

Abstract

Several proteins have been identified that catalyze the import of proteins into peroxisomes. Some recognize specific peroxisomal targeting sequences, but most probably work further downstream the import pathway. Recent evidence suggests that peroxisomal targeting and assembly do not follow the same rules as those for targeting and import into other organelles, such as the mitochondria and the endoplasmic reticulum, i.e. the import of unfolded proteins and subsequent folding within the organelle. Specifically, proteins may be translocated into the peroxisomal matrix in a folded or oligomerized state.

Original languageEnglish (US)
Pages (from-to)54-58
Number of pages5
JournalTrends in Biochemical Sciences
Volume21
Issue number2
DOIs
StatePublished - Jan 1 1996

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Organelles
Proteins
Peroxisomes
Protein Folding
Endoplasmic Reticulum
Mitochondria

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

The targeting and assembly of peroxisomal proteins : Some old rules do not apply. / McNew, James A.; Goodman, Joel M.

In: Trends in Biochemical Sciences, Vol. 21, No. 2, 01.01.1996, p. 54-58.

Research output: Contribution to journalReview article

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