The telomerase challenge - An unusual problem in drug discovery

Anne E. Pitts, David R. Corey

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations

Abstract

Telomerase is a ribonucleoprotein that is responsible for maintaining telomere length. The observation that telomerase activity is found in many types of tumors, but not in adjacent normal tissue, has led to the hypothesis that telomerase is a novel target for chemotherapy. Inhibitors of telomerase activity are essential to validate this hypothesis, and their design presents special opportunities and challenges.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalDrug Discovery Today
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1999

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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