The Texas children's medication algorithm project: Report of the Texas consensus conference panel on medication treatment of childhood major depressive disorder

Carroll W. Hughes, Graham J. Emslie, M. Lynn Crismon, Karen Dineen Wagner, Boris Birmaher, Barbara Geller, Steven R. Pliszka, Neal D. Ryan, Michael Strober, Madhukar H. Trivedi, Marcia G. Toprac, Andrew Sedillo, Maria E. Llana, Molly Lopez, A. John Rush

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Objectives: To develop consensus guidelines for medication treatment algorithms for childhood major depressive disorder (MDD) based on scientific evidence and clinical opinion when science is lacking. The ultimate goal of this approach is to synthesize research and clinical experience for the practitioner and to increase the uniformity of preferred treatment for childhood MDD. A final goal is to develop an approach that can be tested as to whether it improves clinical outcomes for children and adolescents with MDD. Method: A consensus conference was held. Participants included academic clinicians and researchers, practicing clinicians, administrators, consumers, and families. The focus was to review and use clinical evidence to recommend specific pharmacological approaches for treatment of MDD in children and adolescents. After a series of presentations of current research evidence and panel discussion, the consensus panel met, agreed on assumptions, and drafted the algorithms. The process initially addressed strategies of treatment and then tactics to implement the strategies. Results: Consensually agreed-upon algorithms for major depressions (with and without psychosis) and comorbid attention deficit disorders were developed. Treatment strategies emphasized the use of selective serotonin reuptake inhibitor. The algorithm consists of systematic strategies for treatment interventions and recommended tactics for implementation of the strategies, including medication augmentation and medication combinations. Participants recommended prospective evaluation of the algorithms in various public sector settings, and many volunteered as sites for such an evaluation. Conclusions: Using scientific and clinical experience, consensus-derived algorithms for children and adolescents with MDD can be developed.

Original languageEnglish (US)
Pages (from-to)1442-1454
Number of pages13
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume38
Issue number11
StatePublished - 1999

Fingerprint

Major Depressive Disorder
Consensus
Therapeutics
Public Sector
Serotonin Uptake Inhibitors
Attention Deficit Disorder with Hyperactivity
Administrative Personnel
Research
Psychotic Disorders
Research Personnel
Pharmacology
Guidelines
Depression

Keywords

  • Child and adolescent depression
  • Childhood disorders
  • Childhood psychopharmacology
  • Major depressive disorder
  • Medication algorithm
  • Medication consensus conference

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Developmental and Educational Psychology

Cite this

The Texas children's medication algorithm project : Report of the Texas consensus conference panel on medication treatment of childhood major depressive disorder. / Hughes, Carroll W.; Emslie, Graham J.; Lynn Crismon, M.; Wagner, Karen Dineen; Birmaher, Boris; Geller, Barbara; Pliszka, Steven R.; Ryan, Neal D.; Strober, Michael; Trivedi, Madhukar H.; Toprac, Marcia G.; Sedillo, Andrew; Llana, Maria E.; Lopez, Molly; John Rush, A.

In: Journal of the American Academy of Child and Adolescent Psychiatry, Vol. 38, No. 11, 1999, p. 1442-1454.

Research output: Contribution to journalArticle

Hughes, CW, Emslie, GJ, Lynn Crismon, M, Wagner, KD, Birmaher, B, Geller, B, Pliszka, SR, Ryan, ND, Strober, M, Trivedi, MH, Toprac, MG, Sedillo, A, Llana, ME, Lopez, M & John Rush, A 1999, 'The Texas children's medication algorithm project: Report of the Texas consensus conference panel on medication treatment of childhood major depressive disorder', Journal of the American Academy of Child and Adolescent Psychiatry, vol. 38, no. 11, pp. 1442-1454.
Hughes, Carroll W. ; Emslie, Graham J. ; Lynn Crismon, M. ; Wagner, Karen Dineen ; Birmaher, Boris ; Geller, Barbara ; Pliszka, Steven R. ; Ryan, Neal D. ; Strober, Michael ; Trivedi, Madhukar H. ; Toprac, Marcia G. ; Sedillo, Andrew ; Llana, Maria E. ; Lopez, Molly ; John Rush, A. / The Texas children's medication algorithm project : Report of the Texas consensus conference panel on medication treatment of childhood major depressive disorder. In: Journal of the American Academy of Child and Adolescent Psychiatry. 1999 ; Vol. 38, No. 11. pp. 1442-1454.
@article{78365a46e19e4605b3c0c4c4fa8a9e8f,
title = "The Texas children's medication algorithm project: Report of the Texas consensus conference panel on medication treatment of childhood major depressive disorder",
abstract = "Objectives: To develop consensus guidelines for medication treatment algorithms for childhood major depressive disorder (MDD) based on scientific evidence and clinical opinion when science is lacking. The ultimate goal of this approach is to synthesize research and clinical experience for the practitioner and to increase the uniformity of preferred treatment for childhood MDD. A final goal is to develop an approach that can be tested as to whether it improves clinical outcomes for children and adolescents with MDD. Method: A consensus conference was held. Participants included academic clinicians and researchers, practicing clinicians, administrators, consumers, and families. The focus was to review and use clinical evidence to recommend specific pharmacological approaches for treatment of MDD in children and adolescents. After a series of presentations of current research evidence and panel discussion, the consensus panel met, agreed on assumptions, and drafted the algorithms. The process initially addressed strategies of treatment and then tactics to implement the strategies. Results: Consensually agreed-upon algorithms for major depressions (with and without psychosis) and comorbid attention deficit disorders were developed. Treatment strategies emphasized the use of selective serotonin reuptake inhibitor. The algorithm consists of systematic strategies for treatment interventions and recommended tactics for implementation of the strategies, including medication augmentation and medication combinations. Participants recommended prospective evaluation of the algorithms in various public sector settings, and many volunteered as sites for such an evaluation. Conclusions: Using scientific and clinical experience, consensus-derived algorithms for children and adolescents with MDD can be developed.",
keywords = "Child and adolescent depression, Childhood disorders, Childhood psychopharmacology, Major depressive disorder, Medication algorithm, Medication consensus conference",
author = "Hughes, {Carroll W.} and Emslie, {Graham J.} and {Lynn Crismon}, M. and Wagner, {Karen Dineen} and Boris Birmaher and Barbara Geller and Pliszka, {Steven R.} and Ryan, {Neal D.} and Michael Strober and Trivedi, {Madhukar H.} and Toprac, {Marcia G.} and Andrew Sedillo and Llana, {Maria E.} and Molly Lopez and {John Rush}, A.",
year = "1999",
language = "English (US)",
volume = "38",
pages = "1442--1454",
journal = "Journal of the American Academy of Child and Adolescent Psychiatry",
issn = "0890-8567",
publisher = "Elsevier Limited",
number = "11",

}

TY - JOUR

T1 - The Texas children's medication algorithm project

T2 - Report of the Texas consensus conference panel on medication treatment of childhood major depressive disorder

AU - Hughes, Carroll W.

AU - Emslie, Graham J.

AU - Lynn Crismon, M.

AU - Wagner, Karen Dineen

AU - Birmaher, Boris

AU - Geller, Barbara

AU - Pliszka, Steven R.

AU - Ryan, Neal D.

AU - Strober, Michael

AU - Trivedi, Madhukar H.

AU - Toprac, Marcia G.

AU - Sedillo, Andrew

AU - Llana, Maria E.

AU - Lopez, Molly

AU - John Rush, A.

PY - 1999

Y1 - 1999

N2 - Objectives: To develop consensus guidelines for medication treatment algorithms for childhood major depressive disorder (MDD) based on scientific evidence and clinical opinion when science is lacking. The ultimate goal of this approach is to synthesize research and clinical experience for the practitioner and to increase the uniformity of preferred treatment for childhood MDD. A final goal is to develop an approach that can be tested as to whether it improves clinical outcomes for children and adolescents with MDD. Method: A consensus conference was held. Participants included academic clinicians and researchers, practicing clinicians, administrators, consumers, and families. The focus was to review and use clinical evidence to recommend specific pharmacological approaches for treatment of MDD in children and adolescents. After a series of presentations of current research evidence and panel discussion, the consensus panel met, agreed on assumptions, and drafted the algorithms. The process initially addressed strategies of treatment and then tactics to implement the strategies. Results: Consensually agreed-upon algorithms for major depressions (with and without psychosis) and comorbid attention deficit disorders were developed. Treatment strategies emphasized the use of selective serotonin reuptake inhibitor. The algorithm consists of systematic strategies for treatment interventions and recommended tactics for implementation of the strategies, including medication augmentation and medication combinations. Participants recommended prospective evaluation of the algorithms in various public sector settings, and many volunteered as sites for such an evaluation. Conclusions: Using scientific and clinical experience, consensus-derived algorithms for children and adolescents with MDD can be developed.

AB - Objectives: To develop consensus guidelines for medication treatment algorithms for childhood major depressive disorder (MDD) based on scientific evidence and clinical opinion when science is lacking. The ultimate goal of this approach is to synthesize research and clinical experience for the practitioner and to increase the uniformity of preferred treatment for childhood MDD. A final goal is to develop an approach that can be tested as to whether it improves clinical outcomes for children and adolescents with MDD. Method: A consensus conference was held. Participants included academic clinicians and researchers, practicing clinicians, administrators, consumers, and families. The focus was to review and use clinical evidence to recommend specific pharmacological approaches for treatment of MDD in children and adolescents. After a series of presentations of current research evidence and panel discussion, the consensus panel met, agreed on assumptions, and drafted the algorithms. The process initially addressed strategies of treatment and then tactics to implement the strategies. Results: Consensually agreed-upon algorithms for major depressions (with and without psychosis) and comorbid attention deficit disorders were developed. Treatment strategies emphasized the use of selective serotonin reuptake inhibitor. The algorithm consists of systematic strategies for treatment interventions and recommended tactics for implementation of the strategies, including medication augmentation and medication combinations. Participants recommended prospective evaluation of the algorithms in various public sector settings, and many volunteered as sites for such an evaluation. Conclusions: Using scientific and clinical experience, consensus-derived algorithms for children and adolescents with MDD can be developed.

KW - Child and adolescent depression

KW - Childhood disorders

KW - Childhood psychopharmacology

KW - Major depressive disorder

KW - Medication algorithm

KW - Medication consensus conference

UR - http://www.scopus.com/inward/record.url?scp=13044280806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=13044280806&partnerID=8YFLogxK

M3 - Article

C2 - 10560232

AN - SCOPUS:13044280806

VL - 38

SP - 1442

EP - 1454

JO - Journal of the American Academy of Child and Adolescent Psychiatry

JF - Journal of the American Academy of Child and Adolescent Psychiatry

SN - 0890-8567

IS - 11

ER -