The thalamus and multiple sclerosis

Modern views on pathologic, imaging, and clinical aspects

Alireza Minagar, Michael H. Barnett, Ralph H B Benedict, Daniel Pelletier, Istvan Pirko, Mohamad Ali Sahraian, Elliot Frohman, Robert Zivadinov

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

The paired thalamic nuclei are graymatter (GM) structures on both sides of the third ventricle that play major roles in cortical activation, relaying sensory information to the higher cortical centers that influence cognition. Multiple sclerosis (MS) is an immune-mediated disease of the human CNS that affects both the white matter (WM) and GM. A number of clinical observations as well as recent neuropathologic and neuroimaging studies have clearly demonstrated extensive involvement of the thalamus, basal ganglia, and neocortex in patients with MS. Modern MRI techniques permit visualization of GM lesions and measurement of atrophy. These contemporary methods have fundamentally altered our understanding of the pathophysiologic nature of MS. Evidence confirms the contention that GM injury can be detected in the earliest phases of MS, and that iron deposition and atrophy of deep gray nuclei are closely related to the magnitude of inflammation. Extensive involvement of GM, and particularly of the thalamus, is associated with a wide range of clinical manifestations including cognitive decline, motor deficits, fatigue, painful syndromes, and ocular motility disturbances in patients with MS. In this review, we characterize the neuropathologic, neuroimaging, and clinical features of thalamic involvement in MS. Further, we underscore the contention that neuropathologic and neuroimaging correlative investigations of thalamic derangements inMSmay elucidate not heretofore considered pathobiological underpinnings germane to understanding the ontogeny, magnitude, and progression of the disease process.

Original languageEnglish (US)
Pages (from-to)210-219
Number of pages10
JournalNeurology
Volume80
Issue number2
DOIs
StatePublished - Jan 8 2013

Fingerprint

Thalamus
Multiple Sclerosis
Neuroimaging
Atrophy
Thalamic Nuclei
Third Ventricle
Neocortex
Immune System Diseases
Basal Ganglia
Cognition
Fatigue
Disease Progression
Imaging
Iron
Inflammation
Wounds and Injuries

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)

Cite this

Minagar, A., Barnett, M. H., Benedict, R. H. B., Pelletier, D., Pirko, I., Sahraian, M. A., ... Zivadinov, R. (2013). The thalamus and multiple sclerosis: Modern views on pathologic, imaging, and clinical aspects. Neurology, 80(2), 210-219. https://doi.org/10.1212/WNL.0b013e31827b910b

The thalamus and multiple sclerosis : Modern views on pathologic, imaging, and clinical aspects. / Minagar, Alireza; Barnett, Michael H.; Benedict, Ralph H B; Pelletier, Daniel; Pirko, Istvan; Sahraian, Mohamad Ali; Frohman, Elliot; Zivadinov, Robert.

In: Neurology, Vol. 80, No. 2, 08.01.2013, p. 210-219.

Research output: Contribution to journalArticle

Minagar, A, Barnett, MH, Benedict, RHB, Pelletier, D, Pirko, I, Sahraian, MA, Frohman, E & Zivadinov, R 2013, 'The thalamus and multiple sclerosis: Modern views on pathologic, imaging, and clinical aspects', Neurology, vol. 80, no. 2, pp. 210-219. https://doi.org/10.1212/WNL.0b013e31827b910b
Minagar A, Barnett MH, Benedict RHB, Pelletier D, Pirko I, Sahraian MA et al. The thalamus and multiple sclerosis: Modern views on pathologic, imaging, and clinical aspects. Neurology. 2013 Jan 8;80(2):210-219. https://doi.org/10.1212/WNL.0b013e31827b910b
Minagar, Alireza ; Barnett, Michael H. ; Benedict, Ralph H B ; Pelletier, Daniel ; Pirko, Istvan ; Sahraian, Mohamad Ali ; Frohman, Elliot ; Zivadinov, Robert. / The thalamus and multiple sclerosis : Modern views on pathologic, imaging, and clinical aspects. In: Neurology. 2013 ; Vol. 80, No. 2. pp. 210-219.
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