The theory of APL revisited

P. P. Scaglioni; P. P. Pandolfi

The theory of APL revisited

P. P. Scaglioni, P. P. Pandolfi

Research output: Contribution to journal › Article › peer-review

Abstract

Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the retinoic acid receptor α (RARα) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARα fuses to the PML gene in themajority of APL cases, and in a few cases to the PLZF, NPM, NuMA and STAT5b genes. As a consequence, X-RARα and RARα-X fusion genes are generated encoding aberrant chimeric proteins that exert critical oncogenic functions. Here we will integrate some of the most recent findings in APL research in a unified model and discuss some of the outstanding questions that remain to be addressed.

Original language	English (US)
Pages (from-to)	85-100
Number of pages	16
Journal	Current Topics in Microbiology and Immunology
Volume	313
State	Published - 2007

ASJC Scopus subject areas

Immunology and Allergy
Microbiology (medical)
General Immunology and Microbiology
Microbiology

Cite this

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AU - Pandolfi, P. P.

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AB - Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the retinoic acid receptor α (RARα) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARα fuses to the PML gene in themajority of APL cases, and in a few cases to the PLZF, NPM, NuMA and STAT5b genes. As a consequence, X-RARα and RARα-X fusion genes are generated encoding aberrant chimeric proteins that exert critical oncogenic functions. Here we will integrate some of the most recent findings in APL research in a unified model and discuss some of the outstanding questions that remain to be addressed.

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JO - Current Topics in Microbiology and Immunology

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The theory of APL revisited

Abstract

ASJC Scopus subject areas

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