The theory of APL revisited

P. P. Scaglioni, P. P. Pandolfi

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Acute promyelocytic leukemia (APL) is associated with reciprocal and balanced chromosomal translocations always involving the retinoic acid receptor α (RARα) gene on chromosome 17 and variable partner genes (X genes) on distinct chromosomes. RARα fuses to the PML gene in themajority of APL cases, and in a few cases to the PLZF, NPM, NuMA and STAT5b genes. As a consequence, X-RARα and RARα-X fusion genes are generated encoding aberrant chimeric proteins that exert critical oncogenic functions. Here we will integrate some of the most recent findings in APL research in a unified model and discuss some of the outstanding questions that remain to be addressed.

Original languageEnglish (US)
Pages (from-to)85-100
Number of pages16
JournalCurrent Topics in Microbiology and Immunology
Volume313
StatePublished - 2007

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Acute Promyelocytic Leukemia
Retinoic Acid Receptors
Genes
Genetic Translocation
Chromosomes, Human, Pair 17
Gene Fusion
Chromosomes
Research
Proteins

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology (medical)
  • Immunology and Microbiology(all)
  • Microbiology

Cite this

Scaglioni, P. P., & Pandolfi, P. P. (2007). The theory of APL revisited. Current Topics in Microbiology and Immunology, 313, 85-100.

The theory of APL revisited. / Scaglioni, P. P.; Pandolfi, P. P.

In: Current Topics in Microbiology and Immunology, Vol. 313, 2007, p. 85-100.

Research output: Contribution to journalArticle

Scaglioni, PP & Pandolfi, PP 2007, 'The theory of APL revisited', Current Topics in Microbiology and Immunology, vol. 313, pp. 85-100.
Scaglioni, P. P. ; Pandolfi, P. P. / The theory of APL revisited. In: Current Topics in Microbiology and Immunology. 2007 ; Vol. 313. pp. 85-100.
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