The therapeutic potential of cell identity reprogramming for the treatment of aging-related neurodegenerative disorders

Derek K. Smith, Miao He, Chun Li Zhang, Jialin C. Zheng

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Neural cell identity reprogramming strategies aim to treat age-related neurodegenerative disorders with newly induced neurons that regenerate neural architecture and functional circuits in vivo. The isolation and neural differentiation of pluripotent embryonic stem cells provided the first in vitro models of human neurodegenerative disease. Investigation into the molecular mechanisms underlying stem cell pluripotency revealed that somatic cells could be reprogrammed to induced pluripotent stem cells (iPSCs) and these cells could be used to model Alzheimer disease, amyotrophic lateral sclerosis, Huntington disease, and Parkinson disease. Additional neural precursor and direct transdifferentiation strategies further enabled the induction of diverse neural linages and neuron subtypes both in vitro and in vivo. In this review, we highlight neural induction strategies that utilize stem cells, iPSCs, and lineage reprogramming to model or treat age-related neurodegenerative diseases, as well as, the clinical challenges related to neural transplantation and in vivo reprogramming strategies.

Original languageEnglish (US)
JournalProgress in Neurobiology
DOIs
Publication statusAccepted/In press - Sep 11 2015

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Keywords

  • Alzheimer disease
  • Amyotrophic lateral sclerosis
  • Cell identity
  • Embryonic stem cell
  • Huntington disease
  • In vivo reprogramming
  • Induced neural stem cell
  • Induced pluripotent stem cell
  • Neural stem cell
  • Neurodegeneration
  • Neuron
  • Parkinson disease
  • Regenerative medicine
  • Reprogramming
  • Stem cell
  • Transdifferentiation

ASJC Scopus subject areas

  • Neuroscience(all)

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