TY - JOUR
T1 - The THINC-integrated tool (THINC-it) screening assessment for cognitive dysfunction
T2 - Validation in patients with major depressive disorder
AU - McIntyre, Roger S.
AU - Best, Michael W.
AU - Bowie, Christopher R.
AU - Carmona, Nicole E.
AU - Cha, Danielle S.
AU - Lee, Yena
AU - Subramaniapillai, Mehala
AU - Mansur, Rodrigo B.
AU - Barry, Harry
AU - Baune, Bernhard T.
AU - Culpepper, Larry
AU - Fossati, Philippe
AU - Greer, Tracy L.
AU - Harmer, Catherine
AU - Klag, Esther
AU - Lam, Raymond W.
AU - Wittchen, Hans Ulrich
AU - Harrison, John
N1 - Publisher Copyright:
© 2017 Physicians Postgraduate Press, Inc.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Objective: To validate the THINC-integrated tool (THINC-it).a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD). Methods: Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compared to age-, sex-, and education-matched healthy controls (n = 100). Between January and June 2016, subjects completed the THINC-it, which includes variants of the Choice Reaction Time Identification Task (IDN), One-Back Test, Digit Symbol Substitution Test, Trail Making Test.Part B, and the Perceived Deficits Questionnaire for Depression.5-item (PDQ-5-D). Results: The THINC-it required approximately 10 to 15 minutes for administration and was capable of detecting cognitive deficits in adults with MDD. A total of 44.4% of adults with MDD exhibited cognitive performance at ≥ 1.0 SD below that of healthy controls on standardized mean scores of the THINC-it. Concurrent validity of the overall tool, based on a calculated composite score, was acceptable (r = 0.539, P <.001). Concurrent validity of the component tests ranged from -0.083 (IDN) to 0.929 (PDQ-5-D). Qualitative survey results indicated that there was a high level of satisfaction and perceived value in administering the THINC-it regarding its impact on the appropriateness and quality of care being received. Conclusions: The THINC-it is a valid and sensitive tool for detecting cognitive dysfunction in adults with MDD that is free, easy to use, and rapidly administered. The THINC-it should be incorporated into the assessment and measurement of all patients with MDD, particularly among those with enduring functional impairment.
AB - Objective: To validate the THINC-integrated tool (THINC-it).a freely available, patient-administered, computerized screening tool integrating subjective and objective measures of cognitive function in adults with major depressive disorder (MDD). Methods: Subjects aged 18 to 65 years (n = 100) with recurrent MDD experiencing a major depressive episode of at least moderate severity were evaluated and compared to age-, sex-, and education-matched healthy controls (n = 100). Between January and June 2016, subjects completed the THINC-it, which includes variants of the Choice Reaction Time Identification Task (IDN), One-Back Test, Digit Symbol Substitution Test, Trail Making Test.Part B, and the Perceived Deficits Questionnaire for Depression.5-item (PDQ-5-D). Results: The THINC-it required approximately 10 to 15 minutes for administration and was capable of detecting cognitive deficits in adults with MDD. A total of 44.4% of adults with MDD exhibited cognitive performance at ≥ 1.0 SD below that of healthy controls on standardized mean scores of the THINC-it. Concurrent validity of the overall tool, based on a calculated composite score, was acceptable (r = 0.539, P <.001). Concurrent validity of the component tests ranged from -0.083 (IDN) to 0.929 (PDQ-5-D). Qualitative survey results indicated that there was a high level of satisfaction and perceived value in administering the THINC-it regarding its impact on the appropriateness and quality of care being received. Conclusions: The THINC-it is a valid and sensitive tool for detecting cognitive dysfunction in adults with MDD that is free, easy to use, and rapidly administered. The THINC-it should be incorporated into the assessment and measurement of all patients with MDD, particularly among those with enduring functional impairment.
UR - http://www.scopus.com/inward/record.url?scp=85028304450&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028304450&partnerID=8YFLogxK
U2 - 10.4088/JCP.16m11329
DO - 10.4088/JCP.16m11329
M3 - Article
C2 - 28858441
AN - SCOPUS:85028304450
SN - 0160-6689
VL - 78
SP - 873
EP - 881
JO - Journal of Clinical Psychiatry
JF - Journal of Clinical Psychiatry
IS - 7
ER -